Ketamine: behavioral effects of subanesthetic doses
Effects of subanesthetic doses of ketamine (0.25 and 0.5 mg/kg) on memory, cognition, psychomotor function, subjective moods, and incidence of adverse reactions were investigated in 34 healthy young volunteers. The drug caused impairment of immediate and delayed recall. Most of the impairment was du...
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| Veröffentlicht in: | Journal of clinical psychopharmacology 1985-04, Vol.5 (2), p.70-77 |
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| container_end_page | 77 |
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| container_issue | 2 |
| container_start_page | 70 |
| container_title | Journal of clinical psychopharmacology |
| container_volume | 5 |
| creator | GHONEIM, M. M HINRICHS, J. V MEWALDT, S. P PETERSEN, R. C |
| description | Effects of subanesthetic doses of ketamine (0.25 and 0.5 mg/kg) on memory, cognition, psychomotor function, subjective moods, and incidence of adverse reactions were investigated in 34 healthy young volunteers. The drug caused impairment of immediate and delayed recall. Most of the impairment was due to interference with retrieval processes. Recovery was virtually complete 60 minutes after administration. The incidence of adverse reactions was high. Benzodiazepines need to be administered even when ketamine is used in subanesthetic doses. |
| doi_str_mv | 10.1097/00004714-198504000-00003 |
| format | Article |
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M ; HINRICHS, J. V ; MEWALDT, S. P ; PETERSEN, R. C</creator><creatorcontrib>GHONEIM, M. M ; HINRICHS, J. V ; MEWALDT, S. P ; PETERSEN, R. C</creatorcontrib><description>Effects of subanesthetic doses of ketamine (0.25 and 0.5 mg/kg) on memory, cognition, psychomotor function, subjective moods, and incidence of adverse reactions were investigated in 34 healthy young volunteers. The drug caused impairment of immediate and delayed recall. Most of the impairment was due to interference with retrieval processes. Recovery was virtually complete 60 minutes after administration. The incidence of adverse reactions was high. Benzodiazepines need to be administered even when ketamine is used in subanesthetic doses.</description><identifier>ISSN: 0271-0749</identifier><identifier>EISSN: 1533-712X</identifier><identifier>DOI: 10.1097/00004714-198504000-00003</identifier><identifier>PMID: 3988972</identifier><identifier>CODEN: JCPYDR</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Affect - drug effects ; Analgesics ; Biological and medical sciences ; Female ; Headache - chemically induced ; Humans ; Ketamine - pharmacology ; Ketamine - toxicity ; Learning - drug effects ; Male ; Medical sciences ; Memory - drug effects ; Mental Disorders - chemically induced ; Mental Processes - drug effects ; Mental Recall - drug effects ; Nausea - chemically induced ; Neuropharmacology ; Pharmacology. 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C</creatorcontrib><title>Ketamine: behavioral effects of subanesthetic doses</title><title>Journal of clinical psychopharmacology</title><addtitle>J Clin Psychopharmacol</addtitle><description>Effects of subanesthetic doses of ketamine (0.25 and 0.5 mg/kg) on memory, cognition, psychomotor function, subjective moods, and incidence of adverse reactions were investigated in 34 healthy young volunteers. The drug caused impairment of immediate and delayed recall. Most of the impairment was due to interference with retrieval processes. Recovery was virtually complete 60 minutes after administration. The incidence of adverse reactions was high. Benzodiazepines need to be administered even when ketamine is used in subanesthetic doses.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Affect - drug effects</subject><subject>Analgesics</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Headache - chemically induced</subject><subject>Humans</subject><subject>Ketamine - pharmacology</subject><subject>Ketamine - toxicity</subject><subject>Learning - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Mental Disorders - chemically induced</subject><subject>Mental Processes - drug effects</subject><subject>Mental Recall - drug effects</subject><subject>Nausea - chemically induced</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychomotor Performance - drug effects</subject><subject>Vision Disorders - chemically induced</subject><issn>0271-0749</issn><issn>1533-712X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9LA0EMxQdRaq1-BGEPXlcnk91OxpsU_2HBi4K3JTOboSttt-xsBb-9W63NJeS9_AJ5SmWgr0E7e6OHKiwUOTgqdTFM-U7CIzWGEjG3YD6O1VgbC7m2hTtVZyl9ag2FNeVIjdAROWvGCl-k51WzltvMy4K_mrbjZSYxSuhT1sYsbT2vJfUL6ZuQ1W2SdK5OIi-TXOz7RL0_3L_NnvL56-Pz7G6eB0NFn6OLvg4iTntA7WrkmqceyUQSoGCFKQp5X069rSOaEMESoGGvA5NYnCj6uxu6NqVOYrXpmhV33xXoahdD9R9DdYjhV8IBvfxDN1u_kvoA7v8e_Ku9zynwMna8Dk06rDlDYKaEP6FLZYs</recordid><startdate>198504</startdate><enddate>198504</enddate><creator>GHONEIM, M. M</creator><creator>HINRICHS, J. V</creator><creator>MEWALDT, S. P</creator><creator>PETERSEN, R. C</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198504</creationdate><title>Ketamine: behavioral effects of subanesthetic doses</title><author>GHONEIM, M. M ; HINRICHS, J. V ; MEWALDT, S. P ; PETERSEN, R. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-39fbdcee90b1309d3ada6b382f8e18c7ea8fe8bb56b7df32cf178132ab0ca8e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Affect - drug effects</topic><topic>Analgesics</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Headache - chemically induced</topic><topic>Humans</topic><topic>Ketamine - pharmacology</topic><topic>Ketamine - toxicity</topic><topic>Learning - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - drug effects</topic><topic>Mental Disorders - chemically induced</topic><topic>Mental Processes - drug effects</topic><topic>Mental Recall - drug effects</topic><topic>Nausea - chemically induced</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychomotor Performance - drug effects</topic><topic>Vision Disorders - chemically induced</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GHONEIM, M. M</creatorcontrib><creatorcontrib>HINRICHS, J. V</creatorcontrib><creatorcontrib>MEWALDT, S. P</creatorcontrib><creatorcontrib>PETERSEN, R. C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of clinical psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GHONEIM, M. M</au><au>HINRICHS, J. V</au><au>MEWALDT, S. P</au><au>PETERSEN, R. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ketamine: behavioral effects of subanesthetic doses</atitle><jtitle>Journal of clinical psychopharmacology</jtitle><addtitle>J Clin Psychopharmacol</addtitle><date>1985-04</date><risdate>1985</risdate><volume>5</volume><issue>2</issue><spage>70</spage><epage>77</epage><pages>70-77</pages><issn>0271-0749</issn><eissn>1533-712X</eissn><coden>JCPYDR</coden><abstract>Effects of subanesthetic doses of ketamine (0.25 and 0.5 mg/kg) on memory, cognition, psychomotor function, subjective moods, and incidence of adverse reactions were investigated in 34 healthy young volunteers. The drug caused impairment of immediate and delayed recall. Most of the impairment was due to interference with retrieval processes. Recovery was virtually complete 60 minutes after administration. The incidence of adverse reactions was high. Benzodiazepines need to be administered even when ketamine is used in subanesthetic doses.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>3988972</pmid><doi>10.1097/00004714-198504000-00003</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-0749 |
| ispartof | Journal of clinical psychopharmacology, 1985-04, Vol.5 (2), p.70-77 |
| issn | 0271-0749 1533-712X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Affect - drug effects Analgesics Biological and medical sciences Female Headache - chemically induced Humans Ketamine - pharmacology Ketamine - toxicity Learning - drug effects Male Medical sciences Memory - drug effects Mental Disorders - chemically induced Mental Processes - drug effects Mental Recall - drug effects Nausea - chemically induced Neuropharmacology Pharmacology. Drug treatments Psychomotor Performance - drug effects Vision Disorders - chemically induced |
| title | Ketamine: behavioral effects of subanesthetic doses |
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