Ketamine: behavioral effects of subanesthetic doses

Effects of subanesthetic doses of ketamine (0.25 and 0.5 mg/kg) on memory, cognition, psychomotor function, subjective moods, and incidence of adverse reactions were investigated in 34 healthy young volunteers. The drug caused impairment of immediate and delayed recall. Most of the impairment was du...

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Veröffentlicht in:	Journal of clinical psychopharmacology 1985-04, Vol.5 (2), p.70-77
Hauptverfasser:	GHONEIM, M. M, HINRICHS, J. V, MEWALDT, S. P, PETERSEN, R. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Affect - drug effects Analgesics Biological and medical sciences Female Headache - chemically induced Humans Ketamine - pharmacology Ketamine - toxicity Learning - drug effects Male Medical sciences Memory - drug effects Mental Disorders - chemically induced Mental Processes - drug effects Mental Recall - drug effects Nausea - chemically induced Neuropharmacology Pharmacology. Drug treatments Psychomotor Performance - drug effects Vision Disorders - chemically induced
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Zusammenfassung:	Effects of subanesthetic doses of ketamine (0.25 and 0.5 mg/kg) on memory, cognition, psychomotor function, subjective moods, and incidence of adverse reactions were investigated in 34 healthy young volunteers. The drug caused impairment of immediate and delayed recall. Most of the impairment was due to interference with retrieval processes. Recovery was virtually complete 60 minutes after administration. The incidence of adverse reactions was high. Benzodiazepines need to be administered even when ketamine is used in subanesthetic doses.
ISSN:	0271-0749 1533-712X
DOI:	10.1097/00004714-198504000-00003