Antagonism of Renal Angiographic Effects of Cadmium by Zinc

Intrarenal artery administration of 2.0-20.0 mg zinc chloride, unlike cadmium acetate (2.0-20.0 mg), did not significantly alter the renal vasoconstrictive responses elicited by the vasoactive drugs (angiotensin, epinephrine, and norepinephrine). Pretreatment of the renal circulation with zinc ions...

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Veröffentlicht in:	Investigative radiology 1974-09, Vol.9 (5), p.386-395
Hauptverfasser:	Thind, Gurdarshan S, Biery, Darryl N
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiography Angiotensin II - antagonists & inhibitors Animals Cadmium - antagonists & inhibitors Dogs Epinephrine - antagonists & inhibitors Female Kidney - blood supply Kidney - diagnostic imaging Kidney - drug effects Norepinephrine - antagonists & inhibitors Renal Artery - diagnostic imaging Vasoconstrictor Agents - antagonists & inhibitors Vasomotor System - drug effects Zinc - pharmacology
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Zusammenfassung:	Intrarenal artery administration of 2.0-20.0 mg zinc chloride, unlike cadmium acetate (2.0-20.0 mg), did not significantly alter the renal vasoconstrictive responses elicited by the vasoactive drugs (angiotensin, epinephrine, and norepinephrine). Pretreatment of the renal circulation with zinc ions antagonized the cadmium ions; the renal vasculature responded normally to angiotension or catecholamines. The mechanism of the renal protective effect of zinc ions and its pathophysiological implication are discussed.
ISSN:	0020-9996 1536-0210
DOI:	10.1097/00004424-197409000-00009