Site-specific effect of guanosine 3′,5′-cyclic monophosphate phosphodiesterase inhibition in isolated lamb lungs

OBJECTIVE:To determine the effect of combining inhaled nitric oxide (NO) with an inhibitor of guanosine 3′,5′-cyclic monophosphate-specific phosphodiesterase on total and segmental lung resistances. STUDY DESIGN:A controlled laboratory study in isolated blood-perfused lungs prepared from lambs. SETT...

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Veröffentlicht in:	Critical care medicine 2000-02, Vol.28 (2), p.490-495
Hauptverfasser:	Steinhorn, Robin H, Gordon, John B, Tod, Mary L
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Administration, Inhalation Animals Animals, Newborn Biological and medical sciences Cyclic GMP - antagonists & inhibitors Cyclooxygenase Inhibitors - pharmacology Disease Models, Animal Drug Evaluation, Preclinical Drug Synergism Drug Therapy, Combination Hypertension, Pulmonary - chemically induced Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - physiopathology In Vitro Techniques Indomethacin - pharmacology Medical sciences Nitric Oxide - pharmacology Nitric Oxide - therapeutic use Pharmacology. Drug treatments Phosphodiesterase Inhibitors - pharmacology Phosphodiesterase Inhibitors - therapeutic use Purinones - pharmacology Purinones - therapeutic use Respiratory system Time Factors Vascular Resistance - drug effects Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use
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Zusammenfassung:	OBJECTIVE:To determine the effect of combining inhaled nitric oxide (NO) with an inhibitor of guanosine 3′,5′-cyclic monophosphate-specific phosphodiesterase on total and segmental lung resistances. STUDY DESIGN:A controlled laboratory study in isolated blood-perfused lungs prepared from lambs. SETTING:Animal research facility affiliated with a university teaching hospital. SUBJECTS:Five newborn lambs at
ISSN:	0090-3493 1530-0293
DOI:	10.1097/00003246-200002000-00034