Potentiation of magnesium-induced neuromuscular weakness by gentamicin

Potentiation of magnesium-induced neuromuscular weakness by gentamicin

A term neonate with hypermagnesmia secondary to maternal administration of MgSO4 for pre-eclampsia had a respiratory arrest after receiving gentamicin im. The neuromuscular tracings and sequential physician exams done before and after administering gentamicin suggest aminoglycosides may potentiate a...

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Veröffentlicht in:Critical care medicine 1983-01, Vol.11 (1), p.55-56
Hauptverfasser: LʼHOMMEDIEU, CHARLES S, HUBER, PATRICIA A, RASCH, DEBORAH K
Format: Artikel
Sprache:eng
Schlagworte:
Critical Care
Drug Synergism
Female
Gentamicins - adverse effects
Humans
Infant, Newborn
Magnesium - adverse effects
Neuromuscular Diseases - chemically induced
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Zusammenfassung:A term neonate with hypermagnesmia secondary to maternal administration of MgSO4 for pre-eclampsia had a respiratory arrest after receiving gentamicin im. The neuromuscular tracings and sequential physician exams done before and after administering gentamicin suggest aminoglycosides may potentiate a magnesiuminduced impairment of neuromuscular transmission and cause muscular weakness in neonates.
ISSN:0090-3493
1530-0293
DOI:10.1097/00003246-198301000-00015