Different subtype distributions in two cities in Myanmar: evidence for independent clusters of HIV-1 transmission

A molecular epidemiological investigation was conducted in two major cities in Myanmar (Yangon and Mandalay). The study revealed a unique predominance of HIV-1 subtype B' (Thailand variant of subtype B) among injecting drug users in Yangon, indicating the strong founder effect of this variant....

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Veröffentlicht in:	AIDS (London) 2003-03, Vol.17 (4), p.633-636
Hauptverfasser:	MOTOMURA, Kazushi, KUSAGAWA, Shigeru, HIA HTUT LWIN, THWE, Min, KATO, Kayoko, OISHI, Kazunori, YAMAMOTO, Naoki, ZAW, Myint, NAGATAKE, Tsuyoshi, TAKEBE, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Female HIV Infections - epidemiology HIV Infections - transmission HIV Infections - virology HIV-1 - genetics Human viral diseases Humans Infectious diseases Male Medical sciences Molecular Epidemiology Myanmar - epidemiology Sequence Analysis, RNA Substance Abuse, Intravenous Tropical medicine Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Beschreibung
Zusammenfassung:	A molecular epidemiological investigation was conducted in two major cities in Myanmar (Yangon and Mandalay). The study revealed a unique predominance of HIV-1 subtype B' (Thailand variant of subtype B) among injecting drug users in Yangon, indicating the strong founder effect of this variant. In contrast, multiple lineages of HIV-1 strains were found in Mandalay, leading to the evolution of various forms of intersubtype recombinants. The results showed independent clusters of HIV-1 transmission in Myanmar.
ISSN:	0269-9370 1473-5571
DOI:	10.1097/00002030-200303070-00023