Merkel cell carcinoma developing after antithymocyte globulin and cyclosporine therapy for aplastic anemia

We report a patient who developed Merkel cell carcinoma (MCC) after treatment with antithymocyte globulin and cyclosporine for aplastic anemia. The clinical course was progressive and poor prognosis. Although MCC is relatively rare in second cancers arising after immunosuppressive therapy, patients...

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Veröffentlicht in:	Anti-cancer drugs 2003-03, Vol.14 (3), p.251-253
Hauptverfasser:	Takabayashi, Maki, Sakai, Rika, Sakamoto, Hiroshi, Iemoto, Youichi, Kanamori, Heiwa, Inayama, Yoshiaki, Ishigatsubo, Yoshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anemia, Aplastic - drug therapy Antilymphocyte Serum - adverse effects Antilymphocyte Serum - therapeutic use Carcinoma, Merkel Cell - chemically induced Cyclosporine - adverse effects Cyclosporine - therapeutic use Drug Therapy, Combination Female Humans Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use
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Zusammenfassung:	We report a patient who developed Merkel cell carcinoma (MCC) after treatment with antithymocyte globulin and cyclosporine for aplastic anemia. The clinical course was progressive and poor prognosis. Although MCC is relatively rare in second cancers arising after immunosuppressive therapy, patients should be closely monitored for the development of this complication as well as other second malignancies.
ISSN:	0959-4973 1473-5741
DOI:	10.1097/00001813-200303000-00010