Synergism of energy starvation and dextran-conjugated doxorubicin in the killing of multidrug-resistant KB carcinoma cells

Here we report that 2-deoxyglucose/Na azide treatment and free/conjugated doxorubicin are synergistic in cell killing. As demonstrated by fluorescence confocal microscopy, KB-V1 cells retained more conjugated doxorubicin than free doxorubicin. Verapamil or 2-deoxyglucose/Na azide enhanced only the r...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Anti-cancer drugs 1999-02, Vol.10 (2), p.171-178
Hauptverfasser:	Lam, Wing, Chan, Hingleung, Yang, Mengsu, Cheng, Shukhan, Fong, Wangfun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Cell Death - drug effects Cell Nucleus - drug effects Cell Nucleus - metabolism Colchicine - pharmacology Deoxyglucose - pharmacology Dextrans - pharmacology Doxorubicin - metabolism Doxorubicin - pharmacology Drug Resistance, Multiple Drug Resistance, Neoplasm Drug Synergism Energy Metabolism Humans KB Cells - drug effects KB Cells - metabolism Sodium Azide - pharmacology Subcellular Fractions Tumor Cells, Cultured Vinblastine - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Here we report that 2-deoxyglucose/Na azide treatment and free/conjugated doxorubicin are synergistic in cell killing. As demonstrated by fluorescence confocal microscopy, KB-V1 cells retained more conjugated doxorubicin than free doxorubicin. Verapamil or 2-deoxyglucose/Na azide enhanced only the retention of the free drug and the small (
ISSN:	0959-4973 1473-5741
DOI:	10.1097/00001813-199902000-00005