Effects of diallyl sulfide and diallyl disulfide on cisplatin-induced changes in glutathione and glutathione-S-transferase activity

The effects of diallyl sulfide (DAS) and diallyl disulfide (DADS) on cisplatin-induced changes in glutathione (GSH) and glutathione-S-transferase (GST) activity in rat liver and kidney was investigated. Cisplatin treatment significantly (p < 0.05) decreased GSH and GST activity in both liver and...

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Veröffentlicht in:	Anti-cancer drugs 1996-09, Vol.7 (7), p.792-794
Hauptverfasser:	Dwivedi, Chandradhar, Abu-Ghazaleh, Askouhi, Guenther, Jeannine
Format:	Artikel
Sprache:	eng
Schlagworte:	Allyl Compounds Animals Antineoplastic Agents - pharmacology Antioxidants - pharmacology Cisplatin - pharmacology Disulfides - pharmacology Glutathione - metabolism Glutathione Transferase - metabolism Kidney - drug effects Kidney - enzymology Kidney - metabolism Liver - drug effects Liver - enzymology Liver - metabolism Male Rats Rats, Sprague-Dawley Sulfides - pharmacology
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Zusammenfassung:	The effects of diallyl sulfide (DAS) and diallyl disulfide (DADS) on cisplatin-induced changes in glutathione (GSH) and glutathione-S-transferase (GST) activity in rat liver and kidney was investigated. Cisplatin treatment significantly (p < 0.05) decreased GSH and GST activity in both liver and kidney. DADS treatment significantly (p < 0.05) enhanced GSH and GST activity in rat liver and kidney. Furthermore, DADS treatment reversed the effect of cisplatin on GSH and GST activity both in liver and kidney. Administration of DADS with cisplatin could enhance GSH and GST activity and lower cisplatin-induced nephrotoxicity.
ISSN:	0959-4973 1473-5741
DOI:	10.1097/00001813-199609000-00012