1–(2–Tetrahydrofuryl)–5–fluorouracil in combination with uracil suppresses mammary carcinogenesis and growth of tumors induced with 7,12–dimethylbenz[a]anthracene in rats
The effects of 1-(2-tetrahydrofuryl)–5–fluorouracll in combination with uracil (UFT) on mammary carcinogenesis and growth of tumors induced with 7,12-dlmethylbenz– [a]anthracene (DMBA) were Investigated In rats. Daily oral administration of UFT reduced the Incidence and number of mammary tumors comp...
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| Veröffentlicht in: | Anti-cancer drugs 1996-02, Vol.7 (2), p.199-203 |
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| container_title | Anti-cancer drugs |
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| creator | Sakamoto, Shinobu Kudo, Hideki Suzuki, Satoe Sassa, ShuJI Yoshlmura, Shlntarou Nakayama, Tohru Maemura, Masatoshi Mitamura, Tadasu |
| description | The effects of 1-(2-tetrahydrofuryl)–5–fluorouracll in combination with uracil (UFT) on mammary carcinogenesis and growth of tumors induced with 7,12-dlmethylbenz– [a]anthracene (DMBA) were Investigated In rats. Daily oral administration of UFT reduced the Incidence and number of mammary tumors compared with those of the DMBA control group, resulting in lower activities in DNA synthesizing enzymes, thymidylate synthetase and thymldine klnase, and a reduction of bromodeoxyuridlne– Immunoreactlve (S–phase) cells in mammary tumors of UFT–treated rats. |
| doi_str_mv | 10.1097/00001813-199602000-00009 |
| format | Article |
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Daily oral administration of UFT reduced the Incidence and number of mammary tumors compared with those of the DMBA control group, resulting in lower activities in DNA synthesizing enzymes, thymidylate synthetase and thymldine klnase, and a reduction of bromodeoxyuridlne– Immunoreactlve (S–phase) cells in mammary tumors of UFT–treated rats.</description><identifier>ISSN: 0959-4973</identifier><identifier>EISSN: 1473-5741</identifier><identifier>DOI: 10.1097/00001813-199602000-00009</identifier><identifier>PMID: 8740726</identifier><language>eng</language><publisher>England: Lippincott-Raven Publishers</publisher><subject>9,10-Dimethyl-1,2-benzanthracene ; Animals ; Antimetabolites, Antineoplastic - blood ; Antimetabolites, Antineoplastic - pharmacology ; Antimetabolites, Antineoplastic - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - pharmacology ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Body Weight - drug effects ; Bromodeoxyuridine - immunology ; Female ; Hormones - blood ; Immunohistochemistry ; Incidence ; Mammary Neoplasms, Experimental - chemically induced ; Mammary Neoplasms, Experimental - drug therapy ; Mammary Neoplasms, Experimental - epidemiology ; Organ Size - drug effects ; Rats ; Rats, Sprague-Dawley ; Tegafur - blood ; Tegafur - pharmacology ; Tegafur - therapeutic use ; Thymidine Kinase - drug effects ; Thymidine Kinase - metabolism ; Thymidylate Synthase - drug effects ; Thymidylate Synthase - metabolism ; Uracil - blood ; Uracil - pharmacology ; Uracil - therapeutic use</subject><ispartof>Anti-cancer drugs, 1996-02, Vol.7 (2), p.199-203</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8740726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakamoto, Shinobu</creatorcontrib><creatorcontrib>Kudo, Hideki</creatorcontrib><creatorcontrib>Suzuki, Satoe</creatorcontrib><creatorcontrib>Sassa, ShuJI</creatorcontrib><creatorcontrib>Yoshlmura, Shlntarou</creatorcontrib><creatorcontrib>Nakayama, Tohru</creatorcontrib><creatorcontrib>Maemura, Masatoshi</creatorcontrib><creatorcontrib>Mitamura, Tadasu</creatorcontrib><title>1–(2–Tetrahydrofuryl)–5–fluorouracil in combination with uracil suppresses mammary carcinogenesis and growth of tumors induced with 7,12–dimethylbenz[a]anthracene in rats</title><title>Anti-cancer drugs</title><addtitle>Anticancer Drugs</addtitle><description>The effects of 1-(2-tetrahydrofuryl)–5–fluorouracll in combination with uracil (UFT) on mammary carcinogenesis and growth of tumors induced with 7,12-dlmethylbenz– [a]anthracene (DMBA) were Investigated In rats. Daily oral administration of UFT reduced the Incidence and number of mammary tumors compared with those of the DMBA control group, resulting in lower activities in DNA synthesizing enzymes, thymidylate synthetase and thymldine klnase, and a reduction of bromodeoxyuridlne– Immunoreactlve (S–phase) cells in mammary tumors of UFT–treated rats.</description><subject>9,10-Dimethyl-1,2-benzanthracene</subject><subject>Animals</subject><subject>Antimetabolites, Antineoplastic - blood</subject><subject>Antimetabolites, Antineoplastic - pharmacology</subject><subject>Antimetabolites, Antineoplastic - therapeutic use</subject><subject>Antineoplastic Combined Chemotherapy Protocols - pharmacology</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Body Weight - drug effects</subject><subject>Bromodeoxyuridine - immunology</subject><subject>Female</subject><subject>Hormones - blood</subject><subject>Immunohistochemistry</subject><subject>Incidence</subject><subject>Mammary Neoplasms, Experimental - chemically induced</subject><subject>Mammary Neoplasms, Experimental - drug therapy</subject><subject>Mammary Neoplasms, Experimental - epidemiology</subject><subject>Organ Size - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tegafur - blood</subject><subject>Tegafur - pharmacology</subject><subject>Tegafur - therapeutic use</subject><subject>Thymidine Kinase - drug effects</subject><subject>Thymidine Kinase - metabolism</subject><subject>Thymidylate Synthase - drug effects</subject><subject>Thymidylate Synthase - metabolism</subject><subject>Uracil - blood</subject><subject>Uracil - pharmacology</subject><subject>Uracil - therapeutic use</subject><issn>0959-4973</issn><issn>1473-5741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UdFu2yAURdWqLEv7CZV43KS5NQaMeZyidqsUaS_pU1VZ2FzHbLaJACvKnvoP_ZV-0b5kuMnyViRAnMM5F-5BCJP0mqRS3KRxkILQhEiZp1k8JRMkz9CcMEETLhj5gOap5DJhUtCP6JP3v-KNiNMZmhWCpSLL5-iV_H1--ZzFZQ3BqXavnW1Gt---RIjH2XSjdXZ0qjYdNgOubV-ZQQVjB7wzocVHyo_brQPvweNe9b1ye1wrV5vBbmAAbzxWg8YbZ3dRYxscxt46Hx31WIM-WImvZHqJNj2Edt9VMPx5VE9qCG2sEV2m-k4Ff4HOG9V5uDzuC_Rwd7te_khWP7_fL7-tkprGXiQ5KSoCQlYFA5YVRZ5pUrBUSsZpzisgjANvGGdS5VQq3ehcaSGg4jzXlRZ0gYqDb-2s9w6acuvM9LWSpOWUQ_k_h_KUwxsko_TqIN2OVQ_6JDw2PvLswO9sF8D53924A1e2oLrQlu_FS_8BxGyb6A</recordid><startdate>199602</startdate><enddate>199602</enddate><creator>Sakamoto, Shinobu</creator><creator>Kudo, Hideki</creator><creator>Suzuki, Satoe</creator><creator>Sassa, ShuJI</creator><creator>Yoshlmura, Shlntarou</creator><creator>Nakayama, Tohru</creator><creator>Maemura, Masatoshi</creator><creator>Mitamura, Tadasu</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199602</creationdate><title>1–(2–Tetrahydrofuryl)–5–fluorouracil in combination with uracil suppresses mammary carcinogenesis and growth of tumors induced with 7,12–dimethylbenz[a]anthracene in rats</title><author>Sakamoto, Shinobu ; 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Daily oral administration of UFT reduced the Incidence and number of mammary tumors compared with those of the DMBA control group, resulting in lower activities in DNA synthesizing enzymes, thymidylate synthetase and thymldine klnase, and a reduction of bromodeoxyuridlne– Immunoreactlve (S–phase) cells in mammary tumors of UFT–treated rats.</abstract><cop>England</cop><pub>Lippincott-Raven Publishers</pub><pmid>8740726</pmid><doi>10.1097/00001813-199602000-00009</doi><tpages>5</tpages></addata></record> |
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| ispartof | Anti-cancer drugs, 1996-02, Vol.7 (2), p.199-203 |
| issn | 0959-4973 1473-5741 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00001813_199602000_00009 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | 9,10-Dimethyl-1,2-benzanthracene Animals Antimetabolites, Antineoplastic - blood Antimetabolites, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - therapeutic use Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Body Weight - drug effects Bromodeoxyuridine - immunology Female Hormones - blood Immunohistochemistry Incidence Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - epidemiology Organ Size - drug effects Rats Rats, Sprague-Dawley Tegafur - blood Tegafur - pharmacology Tegafur - therapeutic use Thymidine Kinase - drug effects Thymidine Kinase - metabolism Thymidylate Synthase - drug effects Thymidylate Synthase - metabolism Uracil - blood Uracil - pharmacology Uracil - therapeutic use |
| title | 1–(2–Tetrahydrofuryl)–5–fluorouracil in combination with uracil suppresses mammary carcinogenesis and growth of tumors induced with 7,12–dimethylbenz[a]anthracene in rats |
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