1–(2–Tetrahydrofuryl)–5–fluorouracil in combination with uracil suppresses mammary carcinogenesis and growth of tumors induced with 7,12–dimethylbenz[a]anthracene in rats

The effects of 1-(2-tetrahydrofuryl)–5–fluorouracll in combination with uracil (UFT) on mammary carcinogenesis and growth of tumors induced with 7,12-dlmethylbenz– [a]anthracene (DMBA) were Investigated In rats. Daily oral administration of UFT reduced the Incidence and number of mammary tumors compared with those of the DMBA control group, resulting in lower activities in DNA synthesizing enzymes, thymidylate synthetase and thymldine klnase, and a reduction of bromodeoxyuridlne– Immunoreactlve (S–phase) cells in mammary tumors of UFT–treated rats.