Intrathecal sufentanil dose response in nulliparous patients

Intrathecal sufentanil dose response in nulliparous patients

Intrathecal sufentanil provides effective analgesia during the first stage of labor. A range of doses has been reported to provide adequate pain relief. This study determined the dose of intrathecal sufentanil that produced acceptable pain relief in 50% of nulliparous patients (ED50) who requested l...

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Veröffentlicht in:Anesthesiology (Philadelphia) 1998-08, Vol.89 (2), p.364-370
Hauptverfasser: ARKOOSH, V. A, COOPER, M, NORRIS, M. C, BOXER, L, FEROUZ, F, SILVERMAN, N. S, HUFFNAGLE, H. J, HUFFNAGLE, S, LEIGHTON, B. L
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Analgesia, Obstetrical
Analgesics
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - adverse effects
Biological and medical sciences
Blood Pressure - drug effects
Dose-Response Relationship, Drug
Female
Humans
Injections, Spinal
Medical sciences
Neuropharmacology
Pain Measurement
Pharmacology. Drug treatments
Pregnancy
Prospective Studies
Pruritus - chemically induced
Sufentanil - administration & dosage
Sufentanil - adverse effects
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Zusammenfassung:Intrathecal sufentanil provides effective analgesia during the first stage of labor. A range of doses has been reported to provide adequate pain relief. This study determined the dose of intrathecal sufentanil that produced acceptable pain relief in 50% of nulliparous patients (ED50) who requested labor analgesia. With institutional review board approval, 50 nulliparous patients requesting spinal opioid labor analgesia were enrolled into this prospective, randomized, double-blinded study. Each patient was in spontaneous labor at
ISSN:0003-3022
1528-1175
DOI:10.1097/00000542-199808000-00012