Muscle pain occurs after outpatient laparoscopy despite the substitution of vecuronium for succinylcholine

The occurrence, location, and severity of muscle pain were determined when vecuronium was used in lieu of succinylcholine during outpatient laparoscopy. Postoperative muscle pain, in 11 body parts, was assessed by a linear analogue scale questionnaire that was completed by each patient on the evenin...

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Veröffentlicht in:Anesthesiology (Philadelphia) 1989-03, Vol.70 (3), p.408-411
Hauptverfasser: ZAHL, K, APFELBAUM, J. L
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description The occurrence, location, and severity of muscle pain were determined when vecuronium was used in lieu of succinylcholine during outpatient laparoscopy. Postoperative muscle pain, in 11 body parts, was assessed by a linear analogue scale questionnaire that was completed by each patient on the evening of surgery and for the next three mornings. All patients had general endotracheal anesthesia with nitrous oxide, thiopental, and fentanyl. Succinylcholine 1.5 mg/kg (3-4 min after 3 mg of d-tubocurarine) was given to 14 patients for tracheal intubation and then by infusion for additional muscle relaxation. Another 14 patients received vecuronium 50 micrograms/kg iv as the only muscle relaxant used; all of these patients had residual neuromuscular blockade antagonized with glycopyrrolate 7 micrograms/kg and edrophonium 0.5 mg/kg iv. Both groups were similar in age, weight, length of procedure, time to discharge, and amount of thiopental and fentanyl used (P greater than 0.05). No difference was noted in either group with respect to the severity of pain by body part over time. Mean total body pain scores were generated for each group at all four intervals as an alternate type of analysis. No statistical significance was demonstrated by a Student's t test in any group at any interval sampled. The authors failed to demonstrate that the substitution of vecuronium for succinylcholine lowers the incidence of myalgia when used in outpatient diagnostic laparoscopy. They refrain from concluding that vecuronium contributes to postanesthetic myalgia, but feel justified in stating that the avoidance of succinylcholine did not lower the severity or occurrence of muscle pains after laparoscopy when vecuronium was used in its place.
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L</creator><creatorcontrib>ZAHL, K ; APFELBAUM, J. L</creatorcontrib><description>The occurrence, location, and severity of muscle pain were determined when vecuronium was used in lieu of succinylcholine during outpatient laparoscopy. Postoperative muscle pain, in 11 body parts, was assessed by a linear analogue scale questionnaire that was completed by each patient on the evening of surgery and for the next three mornings. All patients had general endotracheal anesthesia with nitrous oxide, thiopental, and fentanyl. Succinylcholine 1.5 mg/kg (3-4 min after 3 mg of d-tubocurarine) was given to 14 patients for tracheal intubation and then by infusion for additional muscle relaxation. Another 14 patients received vecuronium 50 micrograms/kg iv as the only muscle relaxant used; all of these patients had residual neuromuscular blockade antagonized with glycopyrrolate 7 micrograms/kg and edrophonium 0.5 mg/kg iv. Both groups were similar in age, weight, length of procedure, time to discharge, and amount of thiopental and fentanyl used (P greater than 0.05). No difference was noted in either group with respect to the severity of pain by body part over time. Mean total body pain scores were generated for each group at all four intervals as an alternate type of analysis. No statistical significance was demonstrated by a Student's t test in any group at any interval sampled. The authors failed to demonstrate that the substitution of vecuronium for succinylcholine lowers the incidence of myalgia when used in outpatient diagnostic laparoscopy. 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Cell therapy and gene therapy ; Biological and medical sciences ; Drug Evaluation ; Female ; Humans ; Laparoscopy ; Medical sciences ; Muscular Diseases - chemically induced ; Muscular Diseases - epidemiology ; Pain, Postoperative - chemically induced ; Pain, Postoperative - epidemiology ; Prospective Studies ; Random Allocation ; Succinylcholine - adverse effects ; Surveys and Questionnaires ; Vecuronium Bromide - adverse effects</subject><ispartof>Anesthesiology (Philadelphia), 1989-03, Vol.70 (3), p.408-411</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-fe4e816dd78c114c5a1ce441aca3b8b4f025a75414caa2018b3850d088089d723</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=7138909$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2564262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZAHL, K</creatorcontrib><creatorcontrib>APFELBAUM, J. L</creatorcontrib><title>Muscle pain occurs after outpatient laparoscopy despite the substitution of vecuronium for succinylcholine</title><title>Anesthesiology (Philadelphia)</title><addtitle>Anesthesiology</addtitle><description>The occurrence, location, and severity of muscle pain were determined when vecuronium was used in lieu of succinylcholine during outpatient laparoscopy. Postoperative muscle pain, in 11 body parts, was assessed by a linear analogue scale questionnaire that was completed by each patient on the evening of surgery and for the next three mornings. All patients had general endotracheal anesthesia with nitrous oxide, thiopental, and fentanyl. Succinylcholine 1.5 mg/kg (3-4 min after 3 mg of d-tubocurarine) was given to 14 patients for tracheal intubation and then by infusion for additional muscle relaxation. Another 14 patients received vecuronium 50 micrograms/kg iv as the only muscle relaxant used; all of these patients had residual neuromuscular blockade antagonized with glycopyrrolate 7 micrograms/kg and edrophonium 0.5 mg/kg iv. Both groups were similar in age, weight, length of procedure, time to discharge, and amount of thiopental and fentanyl used (P greater than 0.05). No difference was noted in either group with respect to the severity of pain by body part over time. Mean total body pain scores were generated for each group at all four intervals as an alternate type of analysis. No statistical significance was demonstrated by a Student's t test in any group at any interval sampled. The authors failed to demonstrate that the substitution of vecuronium for succinylcholine lowers the incidence of myalgia when used in outpatient diagnostic laparoscopy. They refrain from concluding that vecuronium contributes to postanesthetic myalgia, but feel justified in stating that the avoidance of succinylcholine did not lower the severity or occurrence of muscle pains after laparoscopy when vecuronium was used in its place.</description><subject>Abdominal surgery. Urology. Gynecology. Obstetrics</subject><subject>Ambulatory Surgical Procedures</subject><subject>Anesthesia</subject><subject>Anesthesia depending on type of surgery</subject><subject>Anesthesia, Endotracheal</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Drug Evaluation</subject><subject>Female</subject><subject>Humans</subject><subject>Laparoscopy</subject><subject>Medical sciences</subject><subject>Muscular Diseases - chemically induced</subject><subject>Muscular Diseases - epidemiology</subject><subject>Pain, Postoperative - chemically induced</subject><subject>Pain, Postoperative - epidemiology</subject><subject>Prospective Studies</subject><subject>Random Allocation</subject><subject>Succinylcholine - adverse effects</subject><subject>Surveys and Questionnaires</subject><subject>Vecuronium Bromide - adverse effects</subject><issn>0003-3022</issn><issn>1528-1175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEUhYMotVZ_gpCF29E8m8xSxBdU3Oh6uJNJaMp0MiQZof_e1NZmE3LO-S43ByFMyT0ltXog-yMFq2ita8LLo9or6gzNqWS6olTJczQvEq84YewSXaW02Sck1zM0Y3Ip2JLN0eZjSqa3eAQ_4GDMFBMGl23EYcojZG-HjHsYIYZkwrjDnU2jzxbntcVpalP2eco-FNjhH1v4MPhpi12IxTbGD7verEPvB3uNLhz0yd4c7wX6fnn-enqrVp-v70-Pq8pwXefKWWE1XXad0oZSYSRQY4WgYIC3uhWOMAlKimIBMEJ1y7UkHdGa6LpTjC-QPsw1ZecUrWvG6LcQdw0lzb695r-95tTen6QKentAx6nd2u4EHusq_t3Rh2SgdxEG49Mppmj5Aan5L10NecA</recordid><startdate>19890301</startdate><enddate>19890301</enddate><creator>ZAHL, K</creator><creator>APFELBAUM, J. 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Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Drug Evaluation</topic><topic>Female</topic><topic>Humans</topic><topic>Laparoscopy</topic><topic>Medical sciences</topic><topic>Muscular Diseases - chemically induced</topic><topic>Muscular Diseases - epidemiology</topic><topic>Pain, Postoperative - chemically induced</topic><topic>Pain, Postoperative - epidemiology</topic><topic>Prospective Studies</topic><topic>Random Allocation</topic><topic>Succinylcholine - adverse effects</topic><topic>Surveys and Questionnaires</topic><topic>Vecuronium Bromide - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZAHL, K</creatorcontrib><creatorcontrib>APFELBAUM, J. 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Succinylcholine 1.5 mg/kg (3-4 min after 3 mg of d-tubocurarine) was given to 14 patients for tracheal intubation and then by infusion for additional muscle relaxation. Another 14 patients received vecuronium 50 micrograms/kg iv as the only muscle relaxant used; all of these patients had residual neuromuscular blockade antagonized with glycopyrrolate 7 micrograms/kg and edrophonium 0.5 mg/kg iv. Both groups were similar in age, weight, length of procedure, time to discharge, and amount of thiopental and fentanyl used (P greater than 0.05). No difference was noted in either group with respect to the severity of pain by body part over time. Mean total body pain scores were generated for each group at all four intervals as an alternate type of analysis. No statistical significance was demonstrated by a Student's t test in any group at any interval sampled. The authors failed to demonstrate that the substitution of vecuronium for succinylcholine lowers the incidence of myalgia when used in outpatient diagnostic laparoscopy. They refrain from concluding that vecuronium contributes to postanesthetic myalgia, but feel justified in stating that the avoidance of succinylcholine did not lower the severity or occurrence of muscle pains after laparoscopy when vecuronium was used in its place.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>2564262</pmid><doi>10.1097/00000542-198903000-00007</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
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1528-1175
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source MEDLINE; EZB Electronic Journals Library; Journals@Ovid Complete
subjects Abdominal surgery. Urology. Gynecology. Obstetrics
Ambulatory Surgical Procedures
Anesthesia
Anesthesia depending on type of surgery
Anesthesia, Endotracheal
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Drug Evaluation
Female
Humans
Laparoscopy
Medical sciences
Muscular Diseases - chemically induced
Muscular Diseases - epidemiology
Pain, Postoperative - chemically induced
Pain, Postoperative - epidemiology
Prospective Studies
Random Allocation
Succinylcholine - adverse effects
Surveys and Questionnaires
Vecuronium Bromide - adverse effects
title Muscle pain occurs after outpatient laparoscopy despite the substitution of vecuronium for succinylcholine
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