Histamine Concentrations and Hemodynamic Responses After Remifentamil
Remifentanil is a new potent opioid analgesic that undergoes rapid esterase metabolism.The purpose of this study was to investigate hemodynamic responses to 2-30 micro gram/kg remifentanil (escalating doses) injected as a bolus over 1 min during general anesthesia. After general anesthesia with endo...
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Veröffentlicht in: | Anesthesia and analgesia 1995-05, Vol.80 (5), p.990-993 |
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Sprache: | eng |
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Zusammenfassung: | Remifentanil is a new potent opioid analgesic that undergoes rapid esterase metabolism.The purpose of this study was to investigate hemodynamic responses to 2-30 micro gram/kg remifentanil (escalating doses) injected as a bolus over 1 min during general anesthesia. After general anesthesia with endotracheal intubation, placement of a radial artery catheter, and pretreatment with glycopyrrolate, remifentanil 2, 5, 15, or 30 micro gram/kg (six patients, three male and three female per group) was administered over 1 min. Arterial blood pressure and heart rate were measured noninvasively before drug administration, after drug administration, and then every minute for 5 min. Arterial blood was taken for histamine determinations before drug administration and then at 1, 3, and 5 min after drug administration. Administration of remifentanil was associated with a reduction in systolic blood pressure from 134 +/- 18 to 91 +/- 16 mm Hg and heart rate from 99 +/- 20 to 69 +/- 21 bpm and was not associated with alterations in histamine concentration.(Anesth Analg 1995;80:990-3) |
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ISSN: | 0003-2999 1526-7598 |
DOI: | 10.1097/00000539-199505000-00024 |