Case Report: Toxic Delirium in a Patient Taking Amantadine and Trimethoprim-Sulfamethoxazole

Acute mental confusion occurred in a patient on a stable dose of amantadine after he was started on trimethoprim-sulfamethoxazole. Discontinuation of the drugs led to rapid improvement. Studies in a rat model of organic cation secretion demonstrate that both amantadine and trimethoprim, but not sulf...

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Veröffentlicht in:	The American journal of the medical sciences 1989-12, Vol.298 (6), p.410-412
Hauptverfasser:	Speeg, K.V., Leighton, J.A., Maldonado, A.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amantadine Biological and medical sciences Drug Interaction Drug toxicity and drugs side effects treatment Medical sciences Pharmacology. Drug treatments Renal Secretion Toxicity: nervous system and muscle Trimethoprim
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Zusammenfassung:	Acute mental confusion occurred in a patient on a stable dose of amantadine after he was started on trimethoprim-sulfamethoxazole. Discontinuation of the drugs led to rapid improvement. Studies in a rat model of organic cation secretion demonstrate that both amantadine and trimethoprim, but not sulfamethoxazole, inhibit the renal secretion of the organic cation procainamide. This case may represent an amantadine-trimethoprim interaction.
ISSN:	0002-9629 1538-2990
DOI:	10.1097/00000441-198912000-00010