The neoplastic potential of gastric irradiation. IV: risk estimates

No significant tumor increase was found in the initial analysis of patients irradiated for peptic ulcer and followed through 1962. A preliminary study was undertaken 22 years later to estimate the risk of cancer due to gastric irradiation for peptic ulcer disease. A population of 2,049 irradiated pa...

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Veröffentlicht in:	Am. J. Clin. Oncol.; (United States) 1984-12, Vol.7 (6), p.675-677
Hauptverfasser:	GRIEM, M. L, JUSTMAN, J, WEISS, L
Format:	Artikel
Sprache:	eng
Schlagworte:	550603 - Medicine- External Radiation in Therapy- (1980-) 560151 - Radiation Effects on Animals- Man Biological and medical sciences BODY DATA DIGESTIVE SYSTEM DISEASES DOSES Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen GASTROINTESTINAL TRACT Humans INFORMATION Medical sciences MEDICINE NEOPLASMS Neoplasms, Radiation-Induced - etiology NUCLEAR MEDICINE NUMERICAL DATA ORGANS PATHOLOGICAL CHANGES PATIENTS Peptic Ulcer - radiotherapy RADIATION DOSES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy - adverse effects Risk RISK ASSESSMENT SIDE EFFECTS STATISTICAL DATA STOMACH Stomach Neoplasms - etiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus THERAPY TIME DEPENDENCE Tumors ULCERS
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Beschreibung
Zusammenfassung:	No significant tumor increase was found in the initial analysis of patients irradiated for peptic ulcer and followed through 1962. A preliminary study was undertaken 22 years later to estimate the risk of cancer due to gastric irradiation for peptic ulcer disease. A population of 2,049 irradiated patients and 763 medically managed patients has been identified. A relative risk of 3.7 was found for stomach cancer and an initial risk estimate of 5.5 X 10(-6) excess stomach cancers per person rad was calculated. A more complete follow-up is in progress to further elucidate this observation and decrease the ascertainment bias; however, preliminary data are in agreement with the Japanese atomic bomb reports.
ISSN:	0277-3732 1537-453X
DOI:	10.1097/00000421-198412000-00015