Curcumin induces endothelial mitotic arrest and disrupts tubulin polymerization

Curcumin (CMN), a component of turmeric spice that imparts flavor and color to curry, is a known anti‐inflammatory and angiogenesis‐suppressing bioactive agent. Here, we provide the first evidence that CMN inhibits endothelial cell proliferation via a mechanism involving microtubule depolymerization and mitotic cell cycle arrest. Exposure of bovine aortic endothelial (BAE) cells to 15 μM CMN resulted in significant (P