Early inhibition of the renin angiotensin system prevents development of hypertension in a model of intrauterine growth restriction induced by reduced uterine perfusion in the pregnant rat

Reduced uterine perfusion in the pregnant rat results in growth restricted offspring that develop hypertension around 4 to 6 weeks. The purpose of this study was to determine if early, short‐term blockade of the renin angiotensin system (RAS) prevents development of hypertension in this model of intrauterine growth restriction (IUGR). Weight at birth was significantly reduced in offspring from reduced uterine perfusion dams as compared to offspring from control dams (5.9±0.2 vs. 6.6±0.2 grams, P