Pituitary Follistatin Gene Expression in Female Rats: Evidence That Inhibin Regulates Transcription1

Pituitary Follistatin Gene Expression in Female Rats: Evidence That Inhibin Regulates Transcription1

Follistatin (FS), along with the members of the transforming growth factor β family activin and inhibin, are important regulators of FSH secretion and messenger RNA production. While activin and inhibin appear to function as tonic modulators of FSH (stimulatory and inhibitory, respectively), dynamic...

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Veröffentlicht in:Biology of reproduction 2004-02, Vol.70 (2), p.364-370
Hauptverfasser: Prendergast, Kathleen A, Burger, Laura L, Aylor, Kevin W, Haisenleder, Daniel J, Dalkin, Alan C, Marshall, John C
Format: Artikel
Sprache:eng
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Contents
follicle-stimulating hormone
follistatin
gene regulation
gonadotropin-releasing hormone
inhibin
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Zusammenfassung:Follistatin (FS), along with the members of the transforming growth factor β family activin and inhibin, are important regulators of FSH secretion and messenger RNA production. While activin and inhibin appear to function as tonic modulators of FSH (stimulatory and inhibitory, respectively), dynamic changes in FS are noted through the estrous cycle and under varying physiological experimental paradigms. This suggests that FS is a major contributor to the precisely coordinated secretion of FSH that maintains reproductive function. The aim of this study was to investigate changes in FS, in particular the early (
ISSN:0006-3363
1529-7268
DOI:10.1095/biolreprod.103.021733