Wnt/β-Catenin Signaling Activates and Determines Hepatic Zonal Expression of Glutathione S-Transferases in Mouse Liver

Glutathione S-transferases (GSTs) play an essential role in the elimination of xenobiotic-derived electrophilic metabolites and also catalyze certain steps in the conversion of endogenous molecules. Their expression is controlled by different transcription factors, such as the antioxidant-activated...

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Veröffentlicht in:	Toxicological sciences 2010-05, Vol.115 (1), p.22-33
Hauptverfasser:	Giera, Stefanie, Braeuning, Albert, Köhle, Christoph, Bursch, Wilfried, Metzger, Ute, Buchmann, Albrecht, Schwarz, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - genetics beta Catenin - metabolism Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology drug metabolism Gene Expression Regulation, Enzymologic Glutathione Transferase - genetics Glutathione Transferase - metabolism Ha-ras Hepatocytes - enzymology Hepatocytes - pathology Inactivation, Metabolic - genetics Isoenzymes Liver - enzymology Liver - pathology Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology liver tumor Male metabolic zonation Mice Mice, Inbred C3H Mice, Transgenic Oligonucleotide Array Sequence Analysis phase II Point Mutation Signal Transduction - physiology Wnt1 Protein - genetics Wnt1 Protein - metabolism β-catenin
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