Behavioral Changes in the Rat after Low Doses of Cholinesterase Inhibitors

Behavioral Changes in the Rat after Low Doses of Cholinestease Inhibitors. WOLTHUIS, O. L., AND VANWERSCH, R. A. P. (1984). Fundam. Appl. Toxicol. 4, S195–S208. In rats the acute effects of low doses of five cholinesterase (ChE) inhibitors were investigated in six behavioral tests. Considerable differences were found between the inhibitors studied. TEPP and sarin at doses up to 30% LD50 were without effects. In contrast, soman, physostigmine, and pyridostigmine caused effects at dose levels which did not produce overt symptoms and did not affect running speed and simple coordinated locomotion. Soman (