N-Cadherin as a New Marker for Diagnosis of Diabetic Nephropathy
Abstract Background Diabetic kidney disease (DKD) is a highly prevalent condition worldwide. It represents one of the most frequent complications of diabetes mellitus (DM) and is the primary cause of end-stage renal disease (ESRD). The early detection of inflammatory biomarkers is essential in reduc...
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| Veröffentlicht in: | QJM : An International Journal of Medicine 2024-10, Vol.117 (Supplement_2) |
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| container_title | QJM : An International Journal of Medicine |
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| creator | Ibrahim Seif, Reem Hany Ahmed Sherbeny, Alyaa Ahmed El Bekhet, Meram Mohamed Taha, Bahaa Mahmoud |
| description | Abstract
Background
Diabetic kidney disease (DKD) is a highly prevalent condition worldwide. It represents one of the most frequent complications of diabetes mellitus (DM) and is the primary cause of end-stage renal disease (ESRD). The early detection of inflammatory biomarkers is essential in reducing complications related to the disease.
Objective
To investigate N-Cadherin in serum as a screening and diagnostic indicator for assessing diabetic nephropathy in diabetic patients.
Methods
An observational study carried out in 6 months included 90 patients with type 2 diabetes mellites equally divided into 3 groups: Those without diabetic nephropathy (group 1), those with microalbuminuria (group 2), does with macroalbuminuria (group 3).
Results
N-cadherin levels were increased in diabetic nephropathy compared to those without diabetic nephropathy (p value: 0.000), and most importantly there is significant increase in N-cadherin level between microalbuminuria group and normoalbuminuric (p value: |
| doi_str_mv | 10.1093/qjmed/hcae175.464 |
| format | Article |
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Background
Diabetic kidney disease (DKD) is a highly prevalent condition worldwide. It represents one of the most frequent complications of diabetes mellitus (DM) and is the primary cause of end-stage renal disease (ESRD). The early detection of inflammatory biomarkers is essential in reducing complications related to the disease.
Objective
To investigate N-Cadherin in serum as a screening and diagnostic indicator for assessing diabetic nephropathy in diabetic patients.
Methods
An observational study carried out in 6 months included 90 patients with type 2 diabetes mellites equally divided into 3 groups: Those without diabetic nephropathy (group 1), those with microalbuminuria (group 2), does with macroalbuminuria (group 3).
Results
N-cadherin levels were increased in diabetic nephropathy compared to those without diabetic nephropathy (p value: 0.000), and most importantly there is significant increase in N-cadherin level between microalbuminuria group and normoalbuminuric (p value: <0.001). Also this study revealed significant difference between reading of 3 groups regarding 2hPP, HbA1c, TC, LDL, BUN and creatinine (p value: 0.000, 0.005, 0.003, 0.003, 0.006 and 0.024 respectively). We found a significant negative correlation between N-cadherin and eGFR (P value: 0.014) which indicates that N-cadherin is an important marker in renal disease. Our study had given us an Abstract about the role of the N-cadherin in prediction of detecting DN early and in monitoring treatment outcomes.
Conclusion
This study provides preliminary evidence suggesting N-cadherin as a novel renal biomarker associated with increased albuminuria and decreased eGFR levels in type 2 diabetic patients which can be used as a valuable prognostic and diagnostic tool to slow down or even inhibit ESRD. The study has also demonstrated that N-cadherin levels increased in microalbuminuria group of diabetic nephropathy compared to those without diabetic nephropathy.</description><identifier>ISSN: 1460-2725</identifier><identifier>EISSN: 1460-2393</identifier><identifier>DOI: 10.1093/qjmed/hcae175.464</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>QJM : An International Journal of Medicine, 2024-10, Vol.117 (Supplement_2)</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: journals.permissions@oup.com 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Ibrahim Seif, Reem Hany Ahmed</creatorcontrib><creatorcontrib>Sherbeny, Alyaa Ahmed El</creatorcontrib><creatorcontrib>Bekhet, Meram Mohamed</creatorcontrib><creatorcontrib>Taha, Bahaa Mahmoud</creatorcontrib><title>N-Cadherin as a New Marker for Diagnosis of Diabetic Nephropathy</title><title>QJM : An International Journal of Medicine</title><description>Abstract
Background
Diabetic kidney disease (DKD) is a highly prevalent condition worldwide. It represents one of the most frequent complications of diabetes mellitus (DM) and is the primary cause of end-stage renal disease (ESRD). The early detection of inflammatory biomarkers is essential in reducing complications related to the disease.
Objective
To investigate N-Cadherin in serum as a screening and diagnostic indicator for assessing diabetic nephropathy in diabetic patients.
Methods
An observational study carried out in 6 months included 90 patients with type 2 diabetes mellites equally divided into 3 groups: Those without diabetic nephropathy (group 1), those with microalbuminuria (group 2), does with macroalbuminuria (group 3).
Results
N-cadherin levels were increased in diabetic nephropathy compared to those without diabetic nephropathy (p value: 0.000), and most importantly there is significant increase in N-cadherin level between microalbuminuria group and normoalbuminuric (p value: <0.001). Also this study revealed significant difference between reading of 3 groups regarding 2hPP, HbA1c, TC, LDL, BUN and creatinine (p value: 0.000, 0.005, 0.003, 0.003, 0.006 and 0.024 respectively). We found a significant negative correlation between N-cadherin and eGFR (P value: 0.014) which indicates that N-cadherin is an important marker in renal disease. Our study had given us an Abstract about the role of the N-cadherin in prediction of detecting DN early and in monitoring treatment outcomes.
Conclusion
This study provides preliminary evidence suggesting N-cadherin as a novel renal biomarker associated with increased albuminuria and decreased eGFR levels in type 2 diabetic patients which can be used as a valuable prognostic and diagnostic tool to slow down or even inhibit ESRD. The study has also demonstrated that N-cadherin levels increased in microalbuminuria group of diabetic nephropathy compared to those without diabetic nephropathy.</description><issn>1460-2725</issn><issn>1460-2393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqNkLFOwzAYhC0EEqXwAGx-ANL-dhw73kCBAlIpS3frj2OTFFoHuwj17Ulp2ZnuTrq74SPkmsGEgc6nn6u1a6atRcdUMRFSnJARExIynuv89M8rXpyTi5RWACCUKEfkdpFV2LQudhuKiSJduG_6gvHdRepDpPcdvm1C6hINfh9qt-3sUOrbGHrctrtLcubxI7mro47JcvawrJ6y-evjc3U3z6zSImNCeS41ImDpkXvZoBYWwElZskZZK2Vtm7qWOaKsPVgO3DnLeKFLqfIiHxN2uLUxpBSdN33s1hh3hoHZEzC_BMyRgBkIDJubwyZ89f-o_wBPpV-R</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Ibrahim Seif, Reem Hany Ahmed</creator><creator>Sherbeny, Alyaa Ahmed El</creator><creator>Bekhet, Meram Mohamed</creator><creator>Taha, Bahaa Mahmoud</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20241001</creationdate><title>N-Cadherin as a New Marker for Diagnosis of Diabetic Nephropathy</title><author>Ibrahim Seif, Reem Hany Ahmed ; Sherbeny, Alyaa Ahmed El ; Bekhet, Meram Mohamed ; Taha, Bahaa Mahmoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c794-147f269aa0a8fa2f6da94c00e6681d7cc66bcdbb63aa6bf0c202eec1259867353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ibrahim Seif, Reem Hany Ahmed</creatorcontrib><creatorcontrib>Sherbeny, Alyaa Ahmed El</creatorcontrib><creatorcontrib>Bekhet, Meram Mohamed</creatorcontrib><creatorcontrib>Taha, Bahaa Mahmoud</creatorcontrib><collection>CrossRef</collection><jtitle>QJM : An International Journal of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ibrahim Seif, Reem Hany Ahmed</au><au>Sherbeny, Alyaa Ahmed El</au><au>Bekhet, Meram Mohamed</au><au>Taha, Bahaa Mahmoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-Cadherin as a New Marker for Diagnosis of Diabetic Nephropathy</atitle><jtitle>QJM : An International Journal of Medicine</jtitle><date>2024-10-01</date><risdate>2024</risdate><volume>117</volume><issue>Supplement_2</issue><issn>1460-2725</issn><eissn>1460-2393</eissn><abstract>Abstract
Background
Diabetic kidney disease (DKD) is a highly prevalent condition worldwide. It represents one of the most frequent complications of diabetes mellitus (DM) and is the primary cause of end-stage renal disease (ESRD). The early detection of inflammatory biomarkers is essential in reducing complications related to the disease.
Objective
To investigate N-Cadherin in serum as a screening and diagnostic indicator for assessing diabetic nephropathy in diabetic patients.
Methods
An observational study carried out in 6 months included 90 patients with type 2 diabetes mellites equally divided into 3 groups: Those without diabetic nephropathy (group 1), those with microalbuminuria (group 2), does with macroalbuminuria (group 3).
Results
N-cadherin levels were increased in diabetic nephropathy compared to those without diabetic nephropathy (p value: 0.000), and most importantly there is significant increase in N-cadherin level between microalbuminuria group and normoalbuminuric (p value: <0.001). Also this study revealed significant difference between reading of 3 groups regarding 2hPP, HbA1c, TC, LDL, BUN and creatinine (p value: 0.000, 0.005, 0.003, 0.003, 0.006 and 0.024 respectively). We found a significant negative correlation between N-cadherin and eGFR (P value: 0.014) which indicates that N-cadherin is an important marker in renal disease. Our study had given us an Abstract about the role of the N-cadherin in prediction of detecting DN early and in monitoring treatment outcomes.
Conclusion
This study provides preliminary evidence suggesting N-cadherin as a novel renal biomarker associated with increased albuminuria and decreased eGFR levels in type 2 diabetic patients which can be used as a valuable prognostic and diagnostic tool to slow down or even inhibit ESRD. The study has also demonstrated that N-cadherin levels increased in microalbuminuria group of diabetic nephropathy compared to those without diabetic nephropathy.</abstract><pub>Oxford University Press</pub><doi>10.1093/qjmed/hcae175.464</doi></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current) |
| title | N-Cadherin as a New Marker for Diagnosis of Diabetic Nephropathy |
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