N-Cadherin as a New Marker for Diagnosis of Diabetic Nephropathy

Abstract Background Diabetic kidney disease (DKD) is a highly prevalent condition worldwide. It represents one of the most frequent complications of diabetes mellitus (DM) and is the primary cause of end-stage renal disease (ESRD). The early detection of inflammatory biomarkers is essential in reducing complications related to the disease. Objective To investigate N-Cadherin in serum as a screening and diagnostic indicator for assessing diabetic nephropathy in diabetic patients. Methods An observational study carried out in 6 months included 90 patients with type 2 diabetes mellites equally divided into 3 groups: Those without diabetic nephropathy (group 1), those with microalbuminuria (group 2), does with macroalbuminuria (group 3). Results N-cadherin levels were increased in diabetic nephropathy compared to those without diabetic nephropathy (p value: 0.000), and most importantly there is significant increase in N-cadherin level between microalbuminuria group and normoalbuminuric (p value: