The Correlation between Serum Level of NT-Pro Brain Natriuretic Peptide and Hemodynamically Significant Ventricular Septal Defects

Abstract Background Ventricular septal defect (VSD) is the most common congenital heart disease accounting for 40% of all congenital heart diseases. An isolated VSD accounts for more than 20% of all congenital heart diseases. Aim of the Work We aimed in this study to correlate the serum level of NT Pro-BNP with different 2D and 3D variables and the hemodynamic significance of ventricular septal defects including LV volumes, dimensions, functions and left to right shunt quantification (Qp/Qs) measured by 2D echocardiogram. Patients and Methods Our study included 60 patients in the pediatric age group (up to18 years old) who were referred for elective echocardiogram in the congenital and structural heart disease unit cardiology department in Ain Shams University hospital. Patients with VSD were divided into three equal subgroups according to shunt quantification (Qp/Qs): group (1) included patients with (Qp/Qs 1.5-2) and group (3) included patients with (Qp/Qs >2). Results There was a highly significant positive correlation between Pro-BNP level and echocardiographic shunt quantification by QP_QS (p