Evaluation of the Role of MicroRNA-663a in Pediatric Lupus Nephritis
Abstract Background and Aim Lupus Nephritis (LN) is a serious manifestation of systemic lupus erythematous (SLE) with poor prognosis for pediatric patients resulting in high morbidity and mortality rates. MicroRNAs (miRNAs) are short, non-coding RNAs that serve as epigenetic modulators, affecting ge...
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Veröffentlicht in: | QJM : An International Journal of Medicine 2024-10, Vol.117 (Supplement_2) |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | Abstract
Background and Aim
Lupus Nephritis (LN) is a serious manifestation of systemic lupus erythematous (SLE) with poor prognosis for pediatric patients resulting in high morbidity and mortality rates. MicroRNAs (miRNAs) are short, non-coding RNAs that serve as epigenetic modulators, affecting gene expression and influencing our understanding of disease causes and pathology. Thus, we sought to explore urinary expression of miR-663a in LN among SLE children.
Patients and Methods
The urinary miR-663a expression levels were estimated in cellular pellets from 15 biopsy-proven active LN patients and 15 healthy controls.
Results
LN patients had significantly higher urinary miR-663a expression levels compared to control group (p |
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ISSN: | 1460-2725 1460-2393 |
DOI: | 10.1093/qjmed/hcae175.109 |