Study of the antineoplastic effect of modulating apoptosis-related noncoding RNA in human hepatocellular carcinoma cell line (HepG2)

Study of the antineoplastic effect of modulating apoptosis-related noncoding RNA in human hepatocellular carcinoma cell line (HepG2)

Abstract MiR-421 is considered an important molecule that can prevent tumor growth. Bioinformatics analysis indicated that mRNA caspase-3 gene is a target gene of miR-421. The current study aimed to explore the functional role of miR-421 in hepatocellular carcinoma (HCC) and explore the interaction...

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Veröffentlicht in:QJM : An International Journal of Medicine 2021-10, Vol.114 (Supplement_1)
Hauptverfasser: Sherif, Mai Abdel Azeem, Ismail, Emtiaz Abd-elkawy, Kassim, Samar Kamal, Shehata, Hanan Hussein, Abdel Khalek, Marwa Ali, Abdel Hamid, Marwa Mahmoud
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Sprache:eng
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Zusammenfassung:Abstract MiR-421 is considered an important molecule that can prevent tumor growth. Bioinformatics analysis indicated that mRNA caspase-3 gene is a target gene of miR-421. The current study aimed to explore the functional role of miR-421 in hepatocellular carcinoma (HCC) and explore the interaction between miR-421 and caspase-3. To validate bioinformatics data, RT-qPCR was used to detect the expression of miR-421 and caspase-3 in 10 HCC tissues. The results showed miR-421 expression was significantly higher in HCC than non HCC liver tissues (P
ISSN:1460-2725
1460-2393
DOI:10.1093/qjmed/hcab088.008