Soluble MICA versus Troponin as Early snd Specific Predictor for Acute Myocardial Infarction in Patients with Chronic Kidney Disease

Abstract Background Accurate early detection & early management of MI as a life threatening condition in patients with CKD , who are more likely than those without it to have elevated troponin levels still challenging. Recently, MICA could be activated in the normal tissues by a variety of stimuli, such as ischemia/reperfusion-induced tissue injury. Aim of the Work To compare sensitivity and specificity of serum sMICA to that of Troponin for early and accurate diagnosis of AMI in patients with CKD. Patients and Methods Total 30 patients was enrolled in the study and divided into 2 groups A & B (15 for each one) in NHI , cTnI and sMICA was assayed in both groups; in the group A,cTnI & sMICA was assayed serially according to time from arrival of the patient to ED (0 hour , 3 hours, 6 hours, 12 hours, and 24 hours ) and recording the pattern of rising, peaking & falling of both biomarkers.. ‘ Results At zero hour both markers were positive serum level in both groups but lower in sMICA then pattern of rising and peaking of sMICA was early than TnI in AMI group which peaks later. Conclusion sMICA could be considered as a novel predictor that more sensitive and specific than cTnI.