The Role of Microdosimetry in Radiotherapy
Some of the practical problems encountered in radiation therapy, and in which microdosimetry has contributed or may contribute towards solutions, are reviewed. Microdosimetric methods are especially useful for high LET radiation therapy due to the requirement of quantitative specification of radiati...
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Veröffentlicht in: | Radiation protection dosimetry 1990-06, Vol.31 (1-4), p.421-432 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Some of the practical problems encountered in radiation therapy, and in which microdosimetry has contributed or may contribute towards solutions, are reviewed. Microdosimetric methods are especially useful for high LET radiation therapy due to the requirement of quantitative specification of radiation quality. In neutron therapy, a large number of microdosimetric measurements have been carried out including a systematic set of measurements at European treatment facilities. The correlation with available radiobiological data enabled a pragmatic solution for the specification of radiation quality for fast neutron therapy to be established. Heavy ion therapy requires several parameters to be optimised as a function of the individual clinical situation, the type of particles, the particle energy and the width of the spread-out Bragg peak. The experience gained in fast neutron therapy may provide a suitable basis for employing microdosimetric methods for the specification of radiation quality also in this field. Results of microdosimetric measurements at pi-meson therapy facilities are briefly reported. The measured spectra reveal the presence of a large low LET dose component and furthermore a marked dependence on irradiation parameters. Finally, microdosimetry provides useful information also in the field of low LET radiation therapy, for example in the context of selecting the clinical RBE of 200 kv X-rays and 125I relative to 60Co gamma rays. |
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ISSN: | 0144-8420 1742-3406 |
DOI: | 10.1093/oxfordjournals.rpd.a080707 |