Intestinal-type alkaline phosphatase in urine as an indicator of mercury induced effects on the S3 segment of the proximal tubule

Intestinal-type alkaline phosphatase (IAP) is a specific and sensitive marker for alterations of the S3 segment of the human proximal tubule, the preferred part for several nephrotoxins. We studied IAP and other renal parameters in mercury-exposed workers and their controls. IAP excretion is clearly...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 1992, Vol.7 (3), p.225-229
Hauptverfasser:	Nuyts, G. D., Roels, H. A., Verpooten, G. F., Bernard, A. M., Lauwerys, R. R., Broe, M. E. De
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosaminidase - urine Adult Alkaline Phosphatase - urine Biological and medical sciences Humans intestinal-type alkaline phosphatase Intestines - enzymology Kidney Tubules, Proximal - drug effects Male Medical sciences mercury Mercury - adverse effects Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure S3 segment Tubulopathies
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Zusammenfassung:	Intestinal-type alkaline phosphatase (IAP) is a specific and sensitive marker for alterations of the S3 segment of the human proximal tubule, the preferred part for several nephrotoxins. We studied IAP and other renal parameters in mercury-exposed workers and their controls. IAP excretion is clearly increased in the exposed workers, compared to other parameters, indicating that the determination of this enzyme can be a useful screening test of renal effects in occupational mercury exposure
ISSN:	0931-0509 1460-2385
DOI:	10.1093/oxfordjournals.ndt.a092110