Diagnosis of Renal Proximal Tubular Injury by Urinary Immunoassay for a Proximal Tubular Antigen, the Adenosine Deaminase Binding Protein

Diagnosis of Renal Proximal Tubular Injury by Urinary Immunoassay for a Proximal Tubular Antigen, the Adenosine Deaminase Binding Protein

A sandwich ELISA assay has been formatted from two commercially available murine monoclonal antibodies, URO-4 and URO-4a, directed against a 120 000 dalton glycoprotein, the adenosine deaminase binding protein (ABP), found on the brush border of the renal proximal tubular epithial cell. Untimed urin...

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Veröffentlicht in:Nephrology, dialysis, transplantation dialysis, transplantation, 1987, Vol.2 (3), p.143-148
Hauptverfasser: Tolkoff-Rubin, Nina E., Thompson, R. E., Piper, Donna J., Hansen, W. P., Bander, N. H., Cordon-Cardo, C., Finstad, Connie J., Klotz, L. H., Old, L. J., Rubin, R. H.
Format: Artikel
Sprache:eng
Schlagworte:
ABP (adenosine deaminase binding protein)
Acute Kidney Injury - diagnosis
Adult
Antibodies, Monoclonal
Antigens - urine
Biological and medical sciences
Carrier Proteins - urine
Cystitis - diagnosis
Diagnosis, Differential
Dipeptidyl Peptidase 4
Enzyme-Linked Immunosorbent Assay
Female
Glomerulonephritis - diagnosis
Glycoproteins - immunology
Humans
Kidney Tubular Necrosis, Acute - diagnosis
Kidney Tubules, Proximal - immunology
Male
Medical sciences
Middle Aged
Monoclonal antibodies
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Proximal tubular antigen
Pyelonephritis - diagnosis
Tubulopathies
Uremia - diagnosis
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Zusammenfassung:A sandwich ELISA assay has been formatted from two commercially available murine monoclonal antibodies, URO-4 and URO-4a, directed against a 120 000 dalton glycoprotein, the adenosine deaminase binding protein (ABP), found on the brush border of the renal proximal tubular epithial cell. Untimed urine samples from 37 normal individuals and urinary ABP
ISSN:0931-0509
1460-2385
1460-2385
DOI:10.1093/oxfordjournals.ndt.a091526