A Prospective Randomised Comparative Study on the Influence of Cyclosporin and Azathioprine on Renal Allograft Survival and Function

A Prospective Randomised Comparative Study on the Influence of Cyclosporin and Azathioprine on Renal Allograft Survival and Function

To study the effectiveness and nephrotoxic side-effects of cyclosporin A (CsA) in renal transplant recipients, a prospective randomised trial was designed to compare CsA with azathioprine (Aza). Each treatment group consisted of 40 patients; in the CsA group, 18 were randomly selected for conversion...

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Veröffentlicht in:Nephrology, dialysis, transplantation dialysis, transplantation, 1986, Vol.1 (1), p.44-49
Hauptverfasser: Henny, F. C., Kootte, A. M. M., Van Bockel, J. H., Baldwin, W. M., Hermans, J., Bos, B., van Es, L. A., Paul, L. C.
Format: Artikel
Sprache:eng
Schlagworte:
Azathioprine - adverse effects
Azathioprine - therapeutic use
Clinical Trials as Topic
Cyclosporin
Cyclosporins - adverse effects
Cyclosporins - therapeutic use
Graft Survival - drug effects
Humans
Hypertension
Kidney - drug effects
Kidney Transplantation
Nephrotoxicity
Prospective Studies
Proteinuria
Random Allocation
Renal transplantation
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Zusammenfassung:To study the effectiveness and nephrotoxic side-effects of cyclosporin A (CsA) in renal transplant recipients, a prospective randomised trial was designed to compare CsA with azathioprine (Aza). Each treatment group consisted of 40 patients; in the CsA group, 18 were randomly selected for conversion to Aza after 3 months. The 1-year graft survival for CsA-treated patients was 87% compared with 66% for the Aza group (P=0.033). Anti-rejection therapy was administrated to 78% of the patients in the Aza group and 47% of those in the CsA group (P
ISSN:0931-0509
1460-2385
1460-2385
DOI:10.1093/oxfordjournals.ndt.a091438