Identification of 3β, 7α-Dihydroxychol-5-enoic Acid in Fistula Bile of the Rat Given Cholesterol-4-14C and DL-Mevalonate-2-14C
A Lifschütz positive compound was found in the bile of bile-fistula rats injected with mevalonate-14C or with cholesterol-14C. This compound was identified as 3β, 7α-dihydroxychol-5-enoic acid by thin-layer chromatography and radio-isotope dilution experiments. This finding was taken for a further e...
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| Veröffentlicht in: | Journal of biochemistry (Tokyo) 1972-01, Vol.71 (1), p.85-89 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A Lifschütz positive compound was found in the bile of bile-fistula rats injected with mevalonate-14C or with cholesterol-14C. This compound was identified as 3β, 7α-dihydroxychol-5-enoic acid by thin-layer chromatography and radio-isotope dilution experiments. This finding was taken for a further evidence favorable for a new pathway of chenodeoxycholic acid biogenesis proposed by the authors. |
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| ISSN: | 0021-924X 1756-2651 |
| DOI: | 10.1093/oxfordjournals.jbchem.a129749 |