Efficacy of once daily bisoprolol in stable angina pectoris: an objective comparison with atenolol and long term follow-up

Bisoprolol is a new cardioselective beta-blocker with a long half-life. The efficacy of once daily bisoprolol (10 mg) and atenolol (100 mg) was assessed in 20 patients with stable angina using a placebo controlled double-blind randomized crossover protocol. Efficacy was assessed by computer assisted...

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Veröffentlicht in:	European heart journal 1985-10, Vol.6 (10), p.845-850
Hauptverfasser:	KOHLI, R. S., KHURMI, N. S., KARDASH, M. M., HUGHES, L. O., LAHIRI, A., RAFTERY, E. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adrenergic beta-Antagonists - adverse effects Adrenergic beta-Antagonists - therapeutic use Adult Aged angina pectoris Angina Pectoris - drug therapy atenolol Atenolol - adverse effects Atenolol - therapeutic use Bisoprolol Clinical Trials as Topic Double-Blind Method Drug Administration Schedule Exercise Test Female Follow-Up Studies Hemodynamics - drug effects Humans Male Middle Aged Propanolamines - adverse effects Propanolamines - therapeutic use Random Allocation
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Zusammenfassung:	Bisoprolol is a new cardioselective beta-blocker with a long half-life. The efficacy of once daily bisoprolol (10 mg) and atenolol (100 mg) was assessed in 20 patients with stable angina using a placebo controlled double-blind randomized crossover protocol. Efficacy was assessed by computer assisted treadmill exercise testing with monitoring of leads CMS and CC5, carried out 22–24 h after the last dose. The mean±SEM exercise time on placebo was 6.5±0.4 min increasing to 7.8±0.5 min on bisoprolol (P
ISSN:	0195-668X 1522-9645
DOI:	10.1093/oxfordjournals.eurheartj.a061771