Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study

Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study

Abstract This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V serum concentrations were determined,...

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Veröffentlicht in:Open Forum Infectious Diseases 2021-12, Vol.8 (12), p.ofab573-ofab573, Article 573
Hauptverfasser: Rawson, Timothy M, Wilson, Richard C, Moore, Luke S P, Macgowan, Alasdair P, Lovering, Andrew M, Bayliss, Mark, Kyriakides, Mathew, Gilchrist, Mark, Roberts, Jason A, Hope, William W, Holmes, Alison H
Format: Artikel
Sprache:eng
Schlagworte:
Adults
Analysis
Beta lactamases
Brief Reports
Care and treatment
Immunology
Infection
Infectious Diseases
Life Sciences & Biomedicine
Microbiology
Penicillin
Science & Technology
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Zusammenfassung:Abstract This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V serum concentrations were determined, and a base population PK model was fitted to the data.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofab573