High Prevalence of SARS-CoV-2 Genetic Variation and D614G Mutation in Pediatric Patients With COVID-19

Abstract Background The full spectrum of the disease phenotype and viral genotype of coronavirus disease 2019 (COVID-19) have yet to be thoroughly explored in children. Here, we analyze the relationships between viral genetic variants and clinical characteristics in children. Methods Whole-genome se...

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Veröffentlicht in:	Open Forum Infectious Diseases 2021-06, Vol.8 (6), p.ofaa551, Article 551
Hauptverfasser:	Pandey, Utsav, Yee, Rebecca, Shen, Lishuang, Judkins, Alexander R, Bootwalla, Moiz, Ryutov, Alex, Maglinte, Dennis T, Ostrow, Dejerianne, Precit, Mimi, Biegel, Jaclyn A, Bender, Jeffrey M, Gai, Xiaowu, Dien Bard, Jennifer
Format:	Artikel
Sprache:	eng
Schlagworte:	Children Coronaviruses DNA sequencing Epidemiology Genetic aspects Genomes Genomics Health aspects Immunology Infectious Diseases Life Sciences & Biomedicine Major Medical research Medicine, Experimental Microbiology Nucleotide sequencing Pediatrics Phylogeny Science & Technology Viral genetics Viral proteins
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Zusammenfassung:	Abstract Background The full spectrum of the disease phenotype and viral genotype of coronavirus disease 2019 (COVID-19) have yet to be thoroughly explored in children. Here, we analyze the relationships between viral genetic variants and clinical characteristics in children. Methods Whole-genome sequencing was performed on respiratory specimens collected for all SARS-CoV-2-positive children (n = 141) between March 13 and June 16, 2020. Viral genetic variations across the SARS-CoV-2 genome were identified and investigated to evaluate genomic correlates of disease severity. Results Higher viral load was detected in symptomatic patients (P = .0007) and in children
ISSN:	2328-8957 2328-8957
DOI:	10.1093/ofid/ofaa551