KS03.4.A PATTERNS OF CARE AND CLINICAL OUTCOMES OF PATIENTS WITH GLIOBLASTOMA IN THE UNITED STATES FROM 2005-2020: A REAL-WORLD ANALYSIS

Abstract BACKGROUND Survival for glioblastoma (GBM) remains low, with disparities affecting outcomes. Standard of care (SoC) includes surgery and adjuvant chemoradiation. This study explores the demographics, treatment patterns, and outcomes of GBM pts in the United States (US). MATERIAL AND METHODS We conducted a retrospective study with the US National Cancer Database (NCDB), capturing more than 70% of newly diagnosed patients in US, for GBM pts diagnosed in 2005-2020 according to ESMO Guidance for Reporting Oncology Real-World (GROW). Trends were analyzed with descriptive statistics and X2-test between time periods: 2005-08, 2009-12, 2013-16, and 2017-20. Predictors of SoC receipt were analyzed with multivariate logistic regression. Kaplan-Meier method and log-rank test were used to estimate and compare median overall survival (mOS) for univariate association and Cox proportional-hazards analysis for multivariate modelling. Adjustment was made using demographic, socioeconomic, and clinical factors. Associations were reported as (Odds Ratio [OR]/Hazard Ratio [HR] 95% CI) per STROBE guidelines. RESULTS Of 104,697 GBM pts, 42.5% were female. 91.2% White, 5.7% Black, and 2.0% were Asian. 5.3% were Hispanic. Median age was 65 (IQR 57-73). Percentage of pts ≥ 65 years increased from 48.8% in 2005-08 to 54.0% in 2017-20. 56.5% of pts received SoC. SoC receipt rose over time: 2009-12 (OR 1.26, CI 1.21-1.31, P