1119 Iodine contrast does not contribute to impaired kidney function or need for dialysis

Abstract Background and Aims Imaging diagnostics play a crucial role in the management of patients with acute and critical conditions or suspected underlying disease like infections or malignancy. These examinations are often enhanced by intravenous iodine-based contrast, to improve the imaging quality and the diagnostic accuracy. For long, there has been a conception that these contrast materials are nephrotoxic, but the last decade has provided a significant quantity of modern studies suggesting that this is not the case. The present study evaluates if earlier contrast exposure has contributed to progress in CKD and the need of initiating dialysis treatment in patients who were in maintenance dialysis treatment at the Västerås hospital at the time of inclusion. Method All patients admitted to the dialysis ward in Västerås the 1st of January 2022 were included and copies of all radiology surveys and all lab values from the electronical records for this study population for the last 10 years were extracted to check for contrast exposure. For some patients, this occurred when they were already on maintenance dialysis treatment, others were pre-dialytic at the time or had not yet developed any kidney impairment. For every contrast exposure, we checked the previous creatinine and the earliest creatinine after the examination to check for acute kidney injury, AKI, as defined by KDIGO. As a secondary outcome, we investigated the frequency of examinations where contrast otherwise would be indicated, but was withhold, due to fear of contrast induced AKI. Results In total, 83 patients were included in this study, and among them there were 121 cases of contrast exposure. There were no events of AKI when eGFR was > 30 ml/min. In the subgroup of patients with eGFR