4670 HYPERPARATHYROIDISM DURING 1ST YEAR OF RENAL TRANSPLANT IS ASSOCIATED WITH LONG TERM GRAFT LOSS

Abstract Background and Aims Persistent hyperparathyroidism (HPT) is a frequent problem, especially during the first year after Renal transplant (RTx). We aimed to evaluate the possible association between parathormone (PTH) levels during 1st year of RTx and long-term graft loss (GL) in RTx patients (RTx-p). Method We retrospectively evaluated 871 RTx-p, transplanted in our unit from 2004 to 2020. We measured main renal function and mineral metabolism parameters at 1 month (T1), 6 months (T6) and 12 months (T12) after RTx. Renal outcome was intended as GL during the global follow-up (FU) of 103±60 mths. Results Mean age at RTx was of 49+13 yrs and 58% of RTx-p were male. Most of the RTx-p were on hemodialysis (HD) before RTx (77%) with a mean dialysis vintage of 53+52 months. Most of our cohort (84%) received a kidney from a deceased donor. HPT was highly prevalent during the 1st year of FU; at T1 79% of RTx-p were HPT, of which 63% had secondary HPT (SHPT) and 16% had tertiary HPT (THPT). Comparable prevalence was observed at T6 (HPT 80%; SHPT 64%; THPT 16%) and at T12 (HPT 77%; SHPT 62%; THPT 15%). A strong significant correlation was found between HPT type and GL at every time point [T1 GL: no HPT 6%, SHPT 11% THPT 24%, p