MO812: Risk Factors of Long-Term Hypocalcemia After Parathyroidectomy in Dialysis-Dependent Patients

Abstract BACKGROUND AND AIMS Surgical treatment of secondary hyperparathyroidism (SHPT) is often followed by long-term hypocalcemia, also known as a hungry bone syndrome. We aimed to evaluate the prevalence and risk factors of prolonged hypocalcemia after parathyroidectomy (PTx) for SHPT in dialysis...

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Veröffentlicht in:Nephrology, dialysis, transplantation dialysis, transplantation, 2022-05, Vol.37 (Supplement_3)
Hauptverfasser: Kislyy, Pavel, Parshina, Ekaterina, Zulkarnaev, Aleksei, Tolkach, Alexey
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract BACKGROUND AND AIMS Surgical treatment of secondary hyperparathyroidism (SHPT) is often followed by long-term hypocalcemia, also known as a hungry bone syndrome. We aimed to evaluate the prevalence and risk factors of prolonged hypocalcemia after parathyroidectomy (PTx) for SHPT in dialysis-dependent patients. METHOD The retrospective study included 1711 analyses for total serum calcium (Ca) obtained from 372 patients who underwent PTx (either subtotal or total PTx with autotransplantation of parathyroid tissue) for SHPT between 2011 and 2019 in a tertiary care centre of endocrine surgery. The median age of the patients was 50 (IQR 40–57) years, and the median dialysis duration was 82 (IQR 48–134) months. Preoperative parathyroid hormone level was 136 pmol/L (IQR 99.4–210.4), total serum Ca was 2.43 mmol/L (IQR 2.26–2.57) and alkaline phosphatase (AP) was 183 IU/L (IQR 129–395). Follow-up period after surgery ranged from 3 months to 6 years. Postoperative hypocalcemia was defined as a total serum Ca level
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfac082.010