MO673: Association of Mean Corpuscular Volume with Mortality in Kidney Failure Patients: Opposite Findings in Chinese and Swedish Kidney Failure Patients

Abstract BACKGROUND AND AIMS Higher mean corpuscular volume (MCV), a measure of the average size of the circulating erythrocyte used for differential diagnosis of anemia or for monitoring macrocytosis, is associated with higher mortality in various clinical settings including in patients (pts) with kidney failure; however, results are not consistent and a study from Japan (Honda et al. Low rather than high mean corpuscular volume is associated with mortality in Japanese patients under hemodialysis. Sci Rep. 2020; 10(1): 15 663) found that low MCV associated with mortality in 8571 hemodialysis pts (mean age 62.5 ± 12.7 years, 37.2% female, median MCV 96.1 fL) pts. We investigated the relationship between MCV with all-cause and cardiovascular mortality in two cohorts of kidney failure pts from China and Sweden. METHOD In 731 incident Chinese peritoneal dialysis pts (median age 50 years, 57% males) and 404 Swedish kidney failure pts (median age 56 years, 62% males), baseline MCV and other biochemical and metabolic biomarkers were analysed in relation to mortality during follow-up period of up to 5 years. All-cause and cardiovascular disease (CVD) mortality risk were analysed with competing-risk regression models with transplantation as competing risk adjusting for age, sex, smoking, diabetes, serum albumin, hemoglobulin and calendar year. RESULTS Chinese pts were significantly younger (P