P1201THE AGING OF THE IMMUNE SYSTEM AND FRAGILITY: TWO FEATURES IN PERITONEAL DIALYSIS AND END-STAGE RENAL DISEASE PATIENTS

Abstract Background and Aims Chronic kidney disease (CKD) is associated with premature immune aging and increased inflammatory activity leading into endothelial damage and macrophage senescence (CD14+CD16+). Objective. To evaluate the influence of CKD in senescent immune cells, and its relationship with fragility in patients with nondialysis CKD (ND-CKD) and Peritoneal Dialysis (PD). Method A descriptive transversal study analysing lymphocyte absolute counts and subpopulations in 74 CKD patients (36 DP, 38 ND-CKD) compared with 10 healthy subjects (HS). We also assessed immunoglobulin levels, C3 and C4 fragment complement, Edmonton fragility score and the percentage of proinflammatory blood monocytes with the CD14+CD16+ phenotype. Results PD patients presented more absolute lymphopenia compared with LCC and HS (PD 1194,2, 1589 ND-CKD and 1802 HS; p