P0031IS OXIDATIVE STRESS ASSOCIATED WITH TOTAL KIDNEY VOLUME IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE?

Abstract Background and Aims Ischemia Modified Albumin (IMA) is a marker of cardiovascular risk factor associated with oxidative stress. In this study, our aim was to determine oxidative stress status in autosomal dominant polycystic kidney disease (ADPKD) and to evaluate its relationship with total renal volume. Method Seventy-two ADPKD (mean age 52 (41-64) years) and 33 healthy controls (mean age 54 (42-62) years) (P= 0.372) were included in the study. Total Oxidant Level (TOS) and Total Antioxidant Level (TAS) were measured using the colorimetric method. Oxidative Stress Index (OSI) was calculated. IMA level was measured by ELISA. Total renal volume was assessed by magnetic resonance imaging. The relationship between oxidative stress, inflammation and renal volume was evaluated by correlation analysis. P values