SO029FIRST YEAR RENAL OUTCOME OF TRANSPLANTATIONS OF KIDNEYS FROM HEPATITIS C INFECTED DONORS TO HEPATITIS C NEGATIVE RECIPIENTS

Abstract Background and Aims Transplant centers in US are increasingly willing to transplant kidneys from hepatitis C infected donors to hepatitis C negative recipients. Long-term renal outcome data from non-prophylactic treatment approach outside clinical trials is missing. Method We compared kidne...

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Veröffentlicht in:Nephrology, dialysis, transplantation dialysis, transplantation, 2020-06, Vol.35 (Supplement_3)
Hauptverfasser: Molnar, Miklos Zsolt, Talwar, Manish, Balaraman, Vasanthi, Bhalla, Anshul, Azhar, Ambreen, Yazawa, Masahiko, Tsujita, Makoto, Podila, Pradeep, Nair, Satheesh, Eason, James
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container_issue Supplement_3
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container_title Nephrology, dialysis, transplantation
container_volume 35
creator Molnar, Miklos Zsolt
Talwar, Manish
Balaraman, Vasanthi
Bhalla, Anshul
Azhar, Ambreen
Yazawa, Masahiko
Tsujita, Makoto
Podila, Pradeep
Nair, Satheesh
Eason, James
description Abstract Background and Aims Transplant centers in US are increasingly willing to transplant kidneys from hepatitis C infected donors to hepatitis C negative recipients. Long-term renal outcome data from non-prophylactic treatment approach outside clinical trials is missing. Method We compared kidney graft function of 132 hepatitis C negative recipients, who received HCV infected (NAT+ and antibody+/-; HCV+) versus HCV negative (NAT- and antibody-; HCV-) in 2018, in a single center, retrospective, observational study. Categorical variables were compared using χ2 tests and continuous variables were compared using t-tests or Mann–Whitney U-tests, as appropriate. Linear regression was applied to assess independent association between graft function and HCV viremic status. Results The mean±SD age of recipients was 52±11 years, 44% were female, 20% and 79% of recipients were Caucasian and African-American, respectively. Baseline characteristics were similar between HCV+ vs HCV- groups, except dialysis duration, donors race, KDPI and cold ischemic time (Table). The DGF rate, estimated GFRs at post-transplant 3, 6, 9 and 12 months was similar between HCV+ and HCV- groups (Table). HCV viremic status was not a predictor of 3, 6, 9 and 12 months eGFR in our unadjusted model and after adjustment for donor and recipient characteristics. Conclusion Recipients of HCV-viremic kidneys have similar renal allograft function in the first year after transplantation compared to those who received from HCV-non-viremic kidneys. Table: Parameter Entire cohort HCV+ HCV- P-value Observations (n) 132 73 59 Recipient baseline characteristics Age (years), mean (SD) 52 (11) 52 (11) 52 (12) 0.86 Female gender, N, (%) 58 (44%) 30 (41%) 28 (47%) 0.46 Race, N, (%) Caucasian 27 (20%) 14 (19%) 13 (22%) 0.62 African American 104 (79%) 58 (80%) 46 (78%) Other 1 (1%) 1 (1%) 0 (0%) Dialysis duration (months), median (IQR) 60 (37-87) 49 (30-75) 71 (50-98)
doi_str_mv 10.1093/ndt/gfaa139.SO029
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Long-term renal outcome data from non-prophylactic treatment approach outside clinical trials is missing. Method We compared kidney graft function of 132 hepatitis C negative recipients, who received HCV infected (NAT+ and antibody+/-; HCV+) versus HCV negative (NAT- and antibody-; HCV-) in 2018, in a single center, retrospective, observational study. Categorical variables were compared using χ2 tests and continuous variables were compared using t-tests or Mann–Whitney U-tests, as appropriate. Linear regression was applied to assess independent association between graft function and HCV viremic status. Results The mean±SD age of recipients was 52±11 years, 44% were female, 20% and 79% of recipients were Caucasian and African-American, respectively. Baseline characteristics were similar between HCV+ vs HCV- groups, except dialysis duration, donors race, KDPI and cold ischemic time (Table). The DGF rate, estimated GFRs at post-transplant 3, 6, 9 and 12 months was similar between HCV+ and HCV- groups (Table). HCV viremic status was not a predictor of 3, 6, 9 and 12 months eGFR in our unadjusted model and after adjustment for donor and recipient characteristics. Conclusion Recipients of HCV-viremic kidneys have similar renal allograft function in the first year after transplantation compared to those who received from HCV-non-viremic kidneys. Table: Parameter Entire cohort HCV+ HCV- P-value Observations (n) 132 73 59 Recipient baseline characteristics Age (years), mean (SD) 52 (11) 52 (11) 52 (12) 0.86 Female gender, N, (%) 58 (44%) 30 (41%) 28 (47%) 0.46 Race, N, (%) Caucasian 27 (20%) 14 (19%) 13 (22%) 0.62 African American 104 (79%) 58 (80%) 46 (78%) Other 1 (1%) 1 (1%) 0 (0%) Dialysis duration (months), median (IQR) 60 (37-87) 49 (30-75) 71 (50-98) &lt;0.01 Comorbidity, N, (%) Diabetes 61 (46%) 36 (49%) 25 (42%) 0.43 Hypertension 128 (97%) 71 (97%) 57 (97%) 0.83 Peripheral vascular disease 9 (7%) 8 (11%) 1 (2%) 0.04 Coronary artery disease 21 (16%) 11 (15%) 10 (17%) 0.74 Chronic obstructive pulmonary disease 8 (6%) 5 (7%) 3 (5%) 0.67 Donor Characteristics Age (years), mean (SD) 33 (10) 32 (5) 34 (13) 0.17 Female gender, N, (%) 60 (45%) 37 (47%) 26 (44%) 0.77 DCD, N, (%) 18 (14%) 8 (11%) 10 (17%) 0.32 Comorbidity, N, (%) Diabetes 2 (2%) 1 (1%) 1 (2%) 0.88 Hypertension 12 (9%) 6 (8%) 6 (10%) 0.70 Race, N, (%) Caucasian 107 (82%) 70 (96%) 37 (64%) &lt;0.01 African American 21 (16%) 0 (0%) 21 (36%) Other 3 (2%) 3 (4%) 0 (0%) KDPI, mean (SD) 45 (19) 50 (16) 38 (21) &lt;0.01 Transplant characteristics Cold Ischemic Time (hours), median (IQR) 18.2 (12.7- 21.8) 19.3 (16.2- 23.2) 15.3 (9.1- 20.3) &lt;0.01 ATG dose (mg/kg), mean (SD) 4.9 (0.9) 4.8 (0.8) 5.0 (1.3) 0.25 Renal Outcome Data Delayed Graft Function, N, (%) 13 (10%) 6 (8%) 7 (12%) 0.49 Estimated GFR at 3 months after transplantation (ml/min), mean (SD) 63 (19) 63 (17) 64 (21) 0.76 Estimated GFR at 6 months after transplantation (ml/min), mean (SD) 66 (19) 66 (17) 66 (21) 0.97 Estimated GFR at 9 months after transplantation (ml/min), mean (SD) 66 (17) 66 (15) 67 (20) 0.61 Estimated GFR at 12 months after transplantation (ml/min), mean (SD) 65 (19) 65 (16) 66 (22) 0.65</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfaa139.SO029</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>Nephrology, dialysis, transplantation, 2020-06, Vol.35 (Supplement_3)</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1581,27907,27908</link.rule.ids></links><search><creatorcontrib>Molnar, Miklos Zsolt</creatorcontrib><creatorcontrib>Talwar, Manish</creatorcontrib><creatorcontrib>Balaraman, Vasanthi</creatorcontrib><creatorcontrib>Bhalla, Anshul</creatorcontrib><creatorcontrib>Azhar, Ambreen</creatorcontrib><creatorcontrib>Yazawa, Masahiko</creatorcontrib><creatorcontrib>Tsujita, Makoto</creatorcontrib><creatorcontrib>Podila, Pradeep</creatorcontrib><creatorcontrib>Nair, Satheesh</creatorcontrib><creatorcontrib>Eason, James</creatorcontrib><title>SO029FIRST YEAR RENAL OUTCOME OF TRANSPLANTATIONS OF KIDNEYS FROM HEPATITIS C INFECTED DONORS TO HEPATITIS C NEGATIVE RECIPIENTS</title><title>Nephrology, dialysis, transplantation</title><description>Abstract Background and Aims Transplant centers in US are increasingly willing to transplant kidneys from hepatitis C infected donors to hepatitis C negative recipients. Long-term renal outcome data from non-prophylactic treatment approach outside clinical trials is missing. Method We compared kidney graft function of 132 hepatitis C negative recipients, who received HCV infected (NAT+ and antibody+/-; HCV+) versus HCV negative (NAT- and antibody-; HCV-) in 2018, in a single center, retrospective, observational study. Categorical variables were compared using χ2 tests and continuous variables were compared using t-tests or Mann–Whitney U-tests, as appropriate. Linear regression was applied to assess independent association between graft function and HCV viremic status. Results The mean±SD age of recipients was 52±11 years, 44% were female, 20% and 79% of recipients were Caucasian and African-American, respectively. Baseline characteristics were similar between HCV+ vs HCV- groups, except dialysis duration, donors race, KDPI and cold ischemic time (Table). The DGF rate, estimated GFRs at post-transplant 3, 6, 9 and 12 months was similar between HCV+ and HCV- groups (Table). HCV viremic status was not a predictor of 3, 6, 9 and 12 months eGFR in our unadjusted model and after adjustment for donor and recipient characteristics. Conclusion Recipients of HCV-viremic kidneys have similar renal allograft function in the first year after transplantation compared to those who received from HCV-non-viremic kidneys. Table: Parameter Entire cohort HCV+ HCV- P-value Observations (n) 132 73 59 Recipient baseline characteristics Age (years), mean (SD) 52 (11) 52 (11) 52 (12) 0.86 Female gender, N, (%) 58 (44%) 30 (41%) 28 (47%) 0.46 Race, N, (%) Caucasian 27 (20%) 14 (19%) 13 (22%) 0.62 African American 104 (79%) 58 (80%) 46 (78%) Other 1 (1%) 1 (1%) 0 (0%) Dialysis duration (months), median (IQR) 60 (37-87) 49 (30-75) 71 (50-98) &lt;0.01 Comorbidity, N, (%) Diabetes 61 (46%) 36 (49%) 25 (42%) 0.43 Hypertension 128 (97%) 71 (97%) 57 (97%) 0.83 Peripheral vascular disease 9 (7%) 8 (11%) 1 (2%) 0.04 Coronary artery disease 21 (16%) 11 (15%) 10 (17%) 0.74 Chronic obstructive pulmonary disease 8 (6%) 5 (7%) 3 (5%) 0.67 Donor Characteristics Age (years), mean (SD) 33 (10) 32 (5) 34 (13) 0.17 Female gender, N, (%) 60 (45%) 37 (47%) 26 (44%) 0.77 DCD, N, (%) 18 (14%) 8 (11%) 10 (17%) 0.32 Comorbidity, N, (%) Diabetes 2 (2%) 1 (1%) 1 (2%) 0.88 Hypertension 12 (9%) 6 (8%) 6 (10%) 0.70 Race, N, (%) Caucasian 107 (82%) 70 (96%) 37 (64%) &lt;0.01 African American 21 (16%) 0 (0%) 21 (36%) Other 3 (2%) 3 (4%) 0 (0%) KDPI, mean (SD) 45 (19) 50 (16) 38 (21) &lt;0.01 Transplant characteristics Cold Ischemic Time (hours), median (IQR) 18.2 (12.7- 21.8) 19.3 (16.2- 23.2) 15.3 (9.1- 20.3) &lt;0.01 ATG dose (mg/kg), mean (SD) 4.9 (0.9) 4.8 (0.8) 5.0 (1.3) 0.25 Renal Outcome Data Delayed Graft Function, N, (%) 13 (10%) 6 (8%) 7 (12%) 0.49 Estimated GFR at 3 months after transplantation (ml/min), mean (SD) 63 (19) 63 (17) 64 (21) 0.76 Estimated GFR at 6 months after transplantation (ml/min), mean (SD) 66 (19) 66 (17) 66 (21) 0.97 Estimated GFR at 9 months after transplantation (ml/min), mean (SD) 66 (17) 66 (15) 67 (20) 0.61 Estimated GFR at 12 months after transplantation (ml/min), mean (SD) 65 (19) 65 (16) 66 (22) 0.65</description><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNkE1OwzAQhS0EEqVwAHY-AGntBMfxMkqd1iK1q9ggdRW5ToxAQKsEFuw4Ou7Phh2rGc17b0bzAXCL0QQjlkw_2s_ps7cWJ2yiFYrZGRjh-xRFcZKRczAKHhwhgtgluBqGV4QQiykdgZ-DuRS1NnDN8xrWXOYVVI-mUEsOVQlNnUu9qnJpciOU1PvZg5hJvtawrNUSLvgqKEZoWEAhS14YPoMzJVWtoVF_ZMnnoX_i4UohVoJLo6_BhbdvQ3dzqmNgSm6KRVSpuSjyKnKUsWjTEuJavCEZ9l2KiHXYJ8RTZAn2bkNwklFis5i5LI1x-LnrXNamraedox7bZAzwca3rt8PQd77Z9S_vtv9uMGr2BJtAsDkRbA5QQubumNl-7f5h_wUb8WtQ</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Molnar, Miklos Zsolt</creator><creator>Talwar, Manish</creator><creator>Balaraman, Vasanthi</creator><creator>Bhalla, Anshul</creator><creator>Azhar, Ambreen</creator><creator>Yazawa, Masahiko</creator><creator>Tsujita, Makoto</creator><creator>Podila, Pradeep</creator><creator>Nair, Satheesh</creator><creator>Eason, James</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200601</creationdate><title>SO029FIRST YEAR RENAL OUTCOME OF TRANSPLANTATIONS OF KIDNEYS FROM HEPATITIS C INFECTED DONORS TO HEPATITIS C NEGATIVE RECIPIENTS</title><author>Molnar, Miklos Zsolt ; Talwar, Manish ; Balaraman, Vasanthi ; Bhalla, Anshul ; Azhar, Ambreen ; Yazawa, Masahiko ; Tsujita, Makoto ; Podila, Pradeep ; Nair, Satheesh ; Eason, James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c799-bd55cd1b581fe605ac1f35f70a51fcb513875a829c8621238eec8d6df7ec7f1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Molnar, Miklos Zsolt</creatorcontrib><creatorcontrib>Talwar, Manish</creatorcontrib><creatorcontrib>Balaraman, Vasanthi</creatorcontrib><creatorcontrib>Bhalla, Anshul</creatorcontrib><creatorcontrib>Azhar, Ambreen</creatorcontrib><creatorcontrib>Yazawa, Masahiko</creatorcontrib><creatorcontrib>Tsujita, Makoto</creatorcontrib><creatorcontrib>Podila, Pradeep</creatorcontrib><creatorcontrib>Nair, Satheesh</creatorcontrib><creatorcontrib>Eason, James</creatorcontrib><collection>CrossRef</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Molnar, Miklos Zsolt</au><au>Talwar, Manish</au><au>Balaraman, Vasanthi</au><au>Bhalla, Anshul</au><au>Azhar, Ambreen</au><au>Yazawa, Masahiko</au><au>Tsujita, Makoto</au><au>Podila, Pradeep</au><au>Nair, Satheesh</au><au>Eason, James</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SO029FIRST YEAR RENAL OUTCOME OF TRANSPLANTATIONS OF KIDNEYS FROM HEPATITIS C INFECTED DONORS TO HEPATITIS C NEGATIVE RECIPIENTS</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><date>2020-06-01</date><risdate>2020</risdate><volume>35</volume><issue>Supplement_3</issue><issn>0931-0509</issn><eissn>1460-2385</eissn><abstract>Abstract Background and Aims Transplant centers in US are increasingly willing to transplant kidneys from hepatitis C infected donors to hepatitis C negative recipients. Long-term renal outcome data from non-prophylactic treatment approach outside clinical trials is missing. Method We compared kidney graft function of 132 hepatitis C negative recipients, who received HCV infected (NAT+ and antibody+/-; HCV+) versus HCV negative (NAT- and antibody-; HCV-) in 2018, in a single center, retrospective, observational study. Categorical variables were compared using χ2 tests and continuous variables were compared using t-tests or Mann–Whitney U-tests, as appropriate. Linear regression was applied to assess independent association between graft function and HCV viremic status. Results The mean±SD age of recipients was 52±11 years, 44% were female, 20% and 79% of recipients were Caucasian and African-American, respectively. Baseline characteristics were similar between HCV+ vs HCV- groups, except dialysis duration, donors race, KDPI and cold ischemic time (Table). The DGF rate, estimated GFRs at post-transplant 3, 6, 9 and 12 months was similar between HCV+ and HCV- groups (Table). HCV viremic status was not a predictor of 3, 6, 9 and 12 months eGFR in our unadjusted model and after adjustment for donor and recipient characteristics. Conclusion Recipients of HCV-viremic kidneys have similar renal allograft function in the first year after transplantation compared to those who received from HCV-non-viremic kidneys. Table: Parameter Entire cohort HCV+ HCV- P-value Observations (n) 132 73 59 Recipient baseline characteristics Age (years), mean (SD) 52 (11) 52 (11) 52 (12) 0.86 Female gender, N, (%) 58 (44%) 30 (41%) 28 (47%) 0.46 Race, N, (%) Caucasian 27 (20%) 14 (19%) 13 (22%) 0.62 African American 104 (79%) 58 (80%) 46 (78%) Other 1 (1%) 1 (1%) 0 (0%) Dialysis duration (months), median (IQR) 60 (37-87) 49 (30-75) 71 (50-98) &lt;0.01 Comorbidity, N, (%) Diabetes 61 (46%) 36 (49%) 25 (42%) 0.43 Hypertension 128 (97%) 71 (97%) 57 (97%) 0.83 Peripheral vascular disease 9 (7%) 8 (11%) 1 (2%) 0.04 Coronary artery disease 21 (16%) 11 (15%) 10 (17%) 0.74 Chronic obstructive pulmonary disease 8 (6%) 5 (7%) 3 (5%) 0.67 Donor Characteristics Age (years), mean (SD) 33 (10) 32 (5) 34 (13) 0.17 Female gender, N, (%) 60 (45%) 37 (47%) 26 (44%) 0.77 DCD, N, (%) 18 (14%) 8 (11%) 10 (17%) 0.32 Comorbidity, N, (%) Diabetes 2 (2%) 1 (1%) 1 (2%) 0.88 Hypertension 12 (9%) 6 (8%) 6 (10%) 0.70 Race, N, (%) Caucasian 107 (82%) 70 (96%) 37 (64%) &lt;0.01 African American 21 (16%) 0 (0%) 21 (36%) Other 3 (2%) 3 (4%) 0 (0%) KDPI, mean (SD) 45 (19) 50 (16) 38 (21) &lt;0.01 Transplant characteristics Cold Ischemic Time (hours), median (IQR) 18.2 (12.7- 21.8) 19.3 (16.2- 23.2) 15.3 (9.1- 20.3) &lt;0.01 ATG dose (mg/kg), mean (SD) 4.9 (0.9) 4.8 (0.8) 5.0 (1.3) 0.25 Renal Outcome Data Delayed Graft Function, N, (%) 13 (10%) 6 (8%) 7 (12%) 0.49 Estimated GFR at 3 months after transplantation (ml/min), mean (SD) 63 (19) 63 (17) 64 (21) 0.76 Estimated GFR at 6 months after transplantation (ml/min), mean (SD) 66 (19) 66 (17) 66 (21) 0.97 Estimated GFR at 9 months after transplantation (ml/min), mean (SD) 66 (17) 66 (15) 67 (20) 0.61 Estimated GFR at 12 months after transplantation (ml/min), mean (SD) 65 (19) 65 (16) 66 (22) 0.65</abstract><pub>Oxford University Press</pub><doi>10.1093/ndt/gfaa139.SO029</doi></addata></record>
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title SO029FIRST YEAR RENAL OUTCOME OF TRANSPLANTATIONS OF KIDNEYS FROM HEPATITIS C INFECTED DONORS TO HEPATITIS C NEGATIVE RECIPIENTS
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