SO029FIRST YEAR RENAL OUTCOME OF TRANSPLANTATIONS OF KIDNEYS FROM HEPATITIS C INFECTED DONORS TO HEPATITIS C NEGATIVE RECIPIENTS
Abstract Background and Aims Transplant centers in US are increasingly willing to transplant kidneys from hepatitis C infected donors to hepatitis C negative recipients. Long-term renal outcome data from non-prophylactic treatment approach outside clinical trials is missing. Method We compared kidne...
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creator | Molnar, Miklos Zsolt Talwar, Manish Balaraman, Vasanthi Bhalla, Anshul Azhar, Ambreen Yazawa, Masahiko Tsujita, Makoto Podila, Pradeep Nair, Satheesh Eason, James |
description | Abstract
Background and Aims
Transplant centers in US are increasingly willing to transplant kidneys from hepatitis C infected donors to hepatitis C negative recipients. Long-term renal outcome data from non-prophylactic treatment approach outside clinical trials is missing.
Method
We compared kidney graft function of 132 hepatitis C negative recipients, who received HCV infected (NAT+ and antibody+/-; HCV+) versus HCV negative (NAT- and antibody-; HCV-) in 2018, in a single center, retrospective, observational study. Categorical variables were compared using χ2 tests and continuous variables were compared using t-tests or Mann–Whitney U-tests, as appropriate. Linear regression was applied to assess independent association between graft function and HCV viremic status.
Results
The mean±SD age of recipients was 52±11 years, 44% were female, 20% and 79% of recipients were Caucasian and African-American, respectively. Baseline characteristics were similar between HCV+ vs HCV- groups, except dialysis duration, donors race, KDPI and cold ischemic time (Table). The DGF rate, estimated GFRs at post-transplant 3, 6, 9 and 12 months was similar between HCV+ and HCV- groups (Table). HCV viremic status was not a predictor of 3, 6, 9 and 12 months eGFR in our unadjusted model and after adjustment for donor and recipient characteristics.
Conclusion
Recipients of HCV-viremic kidneys have similar renal allograft function in the first year after transplantation compared to those who received from HCV-non-viremic kidneys.
Table:
Parameter
Entire cohort
HCV+
HCV-
P-value
Observations (n)
132
73
59
Recipient baseline characteristics
Age (years), mean (SD)
52 (11)
52 (11)
52 (12)
0.86
Female gender, N, (%)
58 (44%)
30 (41%)
28 (47%)
0.46
Race, N, (%)
Caucasian
27 (20%)
14 (19%)
13 (22%)
0.62
African American
104 (79%)
58 (80%)
46 (78%)
Other
1 (1%)
1 (1%)
0 (0%)
Dialysis duration (months), median (IQR)
60 (37-87)
49 (30-75)
71 (50-98) |
doi_str_mv | 10.1093/ndt/gfaa139.SO029 |
format | Article |
fullrecord | <record><control><sourceid>oup_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_ndt_gfaa139_SO029</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ndt/gfaa139.SO029</oup_id><sourcerecordid>10.1093/ndt/gfaa139.SO029</sourcerecordid><originalsourceid>FETCH-LOGICAL-c799-bd55cd1b581fe605ac1f35f70a51fcb513875a829c8621238eec8d6df7ec7f1a3</originalsourceid><addsrcrecordid>eNqNkE1OwzAQhS0EEqVwAHY-AGntBMfxMkqd1iK1q9ggdRW5ToxAQKsEFuw4Ou7Phh2rGc17b0bzAXCL0QQjlkw_2s_ps7cWJ2yiFYrZGRjh-xRFcZKRczAKHhwhgtgluBqGV4QQiykdgZ-DuRS1NnDN8xrWXOYVVI-mUEsOVQlNnUu9qnJpciOU1PvZg5hJvtawrNUSLvgqKEZoWEAhS14YPoMzJVWtoVF_ZMnnoX_i4UohVoJLo6_BhbdvQ3dzqmNgSm6KRVSpuSjyKnKUsWjTEuJavCEZ9l2KiHXYJ8RTZAn2bkNwklFis5i5LI1x-LnrXNamraedox7bZAzwca3rt8PQd77Z9S_vtv9uMGr2BJtAsDkRbA5QQubumNl-7f5h_wUb8WtQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>SO029FIRST YEAR RENAL OUTCOME OF TRANSPLANTATIONS OF KIDNEYS FROM HEPATITIS C INFECTED DONORS TO HEPATITIS C NEGATIVE RECIPIENTS</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Molnar, Miklos Zsolt ; Talwar, Manish ; Balaraman, Vasanthi ; Bhalla, Anshul ; Azhar, Ambreen ; Yazawa, Masahiko ; Tsujita, Makoto ; Podila, Pradeep ; Nair, Satheesh ; Eason, James</creator><creatorcontrib>Molnar, Miklos Zsolt ; Talwar, Manish ; Balaraman, Vasanthi ; Bhalla, Anshul ; Azhar, Ambreen ; Yazawa, Masahiko ; Tsujita, Makoto ; Podila, Pradeep ; Nair, Satheesh ; Eason, James</creatorcontrib><description>Abstract
Background and Aims
Transplant centers in US are increasingly willing to transplant kidneys from hepatitis C infected donors to hepatitis C negative recipients. Long-term renal outcome data from non-prophylactic treatment approach outside clinical trials is missing.
Method
We compared kidney graft function of 132 hepatitis C negative recipients, who received HCV infected (NAT+ and antibody+/-; HCV+) versus HCV negative (NAT- and antibody-; HCV-) in 2018, in a single center, retrospective, observational study. Categorical variables were compared using χ2 tests and continuous variables were compared using t-tests or Mann–Whitney U-tests, as appropriate. Linear regression was applied to assess independent association between graft function and HCV viremic status.
Results
The mean±SD age of recipients was 52±11 years, 44% were female, 20% and 79% of recipients were Caucasian and African-American, respectively. Baseline characteristics were similar between HCV+ vs HCV- groups, except dialysis duration, donors race, KDPI and cold ischemic time (Table). The DGF rate, estimated GFRs at post-transplant 3, 6, 9 and 12 months was similar between HCV+ and HCV- groups (Table). HCV viremic status was not a predictor of 3, 6, 9 and 12 months eGFR in our unadjusted model and after adjustment for donor and recipient characteristics.
Conclusion
Recipients of HCV-viremic kidneys have similar renal allograft function in the first year after transplantation compared to those who received from HCV-non-viremic kidneys.
Table:
Parameter
Entire cohort
HCV+
HCV-
P-value
Observations (n)
132
73
59
Recipient baseline characteristics
Age (years), mean (SD)
52 (11)
52 (11)
52 (12)
0.86
Female gender, N, (%)
58 (44%)
30 (41%)
28 (47%)
0.46
Race, N, (%)
Caucasian
27 (20%)
14 (19%)
13 (22%)
0.62
African American
104 (79%)
58 (80%)
46 (78%)
Other
1 (1%)
1 (1%)
0 (0%)
Dialysis duration (months), median (IQR)
60 (37-87)
49 (30-75)
71 (50-98)
<0.01
Comorbidity, N, (%)
Diabetes
61 (46%)
36 (49%)
25 (42%)
0.43
Hypertension
128 (97%)
71 (97%)
57 (97%)
0.83
Peripheral vascular disease
9 (7%)
8 (11%)
1 (2%)
0.04
Coronary artery disease
21 (16%)
11 (15%)
10 (17%)
0.74
Chronic obstructive pulmonary disease
8 (6%)
5 (7%)
3 (5%)
0.67
Donor Characteristics
Age (years), mean (SD)
33 (10)
32 (5)
34 (13)
0.17
Female gender, N, (%)
60 (45%)
37 (47%)
26 (44%)
0.77
DCD, N, (%)
18 (14%)
8 (11%)
10 (17%)
0.32
Comorbidity, N, (%)
Diabetes
2 (2%)
1 (1%)
1 (2%)
0.88
Hypertension
12 (9%)
6 (8%)
6 (10%)
0.70
Race, N, (%)
Caucasian
107 (82%)
70 (96%)
37 (64%)
<0.01
African American
21 (16%)
0 (0%)
21 (36%)
Other
3 (2%)
3 (4%)
0 (0%)
KDPI, mean (SD)
45 (19)
50 (16)
38 (21)
<0.01
Transplant characteristics
Cold Ischemic Time (hours), median (IQR)
18.2 (12.7- 21.8)
19.3 (16.2- 23.2)
15.3 (9.1- 20.3)
<0.01
ATG dose (mg/kg), mean (SD)
4.9 (0.9)
4.8 (0.8)
5.0 (1.3)
0.25
Renal Outcome Data
Delayed Graft Function, N, (%)
13 (10%)
6 (8%)
7 (12%)
0.49
Estimated GFR at 3 months after transplantation (ml/min), mean (SD)
63 (19)
63 (17)
64 (21)
0.76
Estimated GFR at 6 months after transplantation (ml/min), mean (SD)
66 (19)
66 (17)
66 (21)
0.97
Estimated GFR at 9 months after transplantation (ml/min), mean (SD)
66 (17)
66 (15)
67 (20)
0.61
Estimated GFR at 12 months after transplantation (ml/min), mean (SD)
65 (19)
65 (16)
66 (22)
0.65</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfaa139.SO029</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>Nephrology, dialysis, transplantation, 2020-06, Vol.35 (Supplement_3)</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1581,27907,27908</link.rule.ids></links><search><creatorcontrib>Molnar, Miklos Zsolt</creatorcontrib><creatorcontrib>Talwar, Manish</creatorcontrib><creatorcontrib>Balaraman, Vasanthi</creatorcontrib><creatorcontrib>Bhalla, Anshul</creatorcontrib><creatorcontrib>Azhar, Ambreen</creatorcontrib><creatorcontrib>Yazawa, Masahiko</creatorcontrib><creatorcontrib>Tsujita, Makoto</creatorcontrib><creatorcontrib>Podila, Pradeep</creatorcontrib><creatorcontrib>Nair, Satheesh</creatorcontrib><creatorcontrib>Eason, James</creatorcontrib><title>SO029FIRST YEAR RENAL OUTCOME OF TRANSPLANTATIONS OF KIDNEYS FROM HEPATITIS C INFECTED DONORS TO HEPATITIS C NEGATIVE RECIPIENTS</title><title>Nephrology, dialysis, transplantation</title><description>Abstract
Background and Aims
Transplant centers in US are increasingly willing to transplant kidneys from hepatitis C infected donors to hepatitis C negative recipients. Long-term renal outcome data from non-prophylactic treatment approach outside clinical trials is missing.
Method
We compared kidney graft function of 132 hepatitis C negative recipients, who received HCV infected (NAT+ and antibody+/-; HCV+) versus HCV negative (NAT- and antibody-; HCV-) in 2018, in a single center, retrospective, observational study. Categorical variables were compared using χ2 tests and continuous variables were compared using t-tests or Mann–Whitney U-tests, as appropriate. Linear regression was applied to assess independent association between graft function and HCV viremic status.
Results
The mean±SD age of recipients was 52±11 years, 44% were female, 20% and 79% of recipients were Caucasian and African-American, respectively. Baseline characteristics were similar between HCV+ vs HCV- groups, except dialysis duration, donors race, KDPI and cold ischemic time (Table). The DGF rate, estimated GFRs at post-transplant 3, 6, 9 and 12 months was similar between HCV+ and HCV- groups (Table). HCV viremic status was not a predictor of 3, 6, 9 and 12 months eGFR in our unadjusted model and after adjustment for donor and recipient characteristics.
Conclusion
Recipients of HCV-viremic kidneys have similar renal allograft function in the first year after transplantation compared to those who received from HCV-non-viremic kidneys.
Table:
Parameter
Entire cohort
HCV+
HCV-
P-value
Observations (n)
132
73
59
Recipient baseline characteristics
Age (years), mean (SD)
52 (11)
52 (11)
52 (12)
0.86
Female gender, N, (%)
58 (44%)
30 (41%)
28 (47%)
0.46
Race, N, (%)
Caucasian
27 (20%)
14 (19%)
13 (22%)
0.62
African American
104 (79%)
58 (80%)
46 (78%)
Other
1 (1%)
1 (1%)
0 (0%)
Dialysis duration (months), median (IQR)
60 (37-87)
49 (30-75)
71 (50-98)
<0.01
Comorbidity, N, (%)
Diabetes
61 (46%)
36 (49%)
25 (42%)
0.43
Hypertension
128 (97%)
71 (97%)
57 (97%)
0.83
Peripheral vascular disease
9 (7%)
8 (11%)
1 (2%)
0.04
Coronary artery disease
21 (16%)
11 (15%)
10 (17%)
0.74
Chronic obstructive pulmonary disease
8 (6%)
5 (7%)
3 (5%)
0.67
Donor Characteristics
Age (years), mean (SD)
33 (10)
32 (5)
34 (13)
0.17
Female gender, N, (%)
60 (45%)
37 (47%)
26 (44%)
0.77
DCD, N, (%)
18 (14%)
8 (11%)
10 (17%)
0.32
Comorbidity, N, (%)
Diabetes
2 (2%)
1 (1%)
1 (2%)
0.88
Hypertension
12 (9%)
6 (8%)
6 (10%)
0.70
Race, N, (%)
Caucasian
107 (82%)
70 (96%)
37 (64%)
<0.01
African American
21 (16%)
0 (0%)
21 (36%)
Other
3 (2%)
3 (4%)
0 (0%)
KDPI, mean (SD)
45 (19)
50 (16)
38 (21)
<0.01
Transplant characteristics
Cold Ischemic Time (hours), median (IQR)
18.2 (12.7- 21.8)
19.3 (16.2- 23.2)
15.3 (9.1- 20.3)
<0.01
ATG dose (mg/kg), mean (SD)
4.9 (0.9)
4.8 (0.8)
5.0 (1.3)
0.25
Renal Outcome Data
Delayed Graft Function, N, (%)
13 (10%)
6 (8%)
7 (12%)
0.49
Estimated GFR at 3 months after transplantation (ml/min), mean (SD)
63 (19)
63 (17)
64 (21)
0.76
Estimated GFR at 6 months after transplantation (ml/min), mean (SD)
66 (19)
66 (17)
66 (21)
0.97
Estimated GFR at 9 months after transplantation (ml/min), mean (SD)
66 (17)
66 (15)
67 (20)
0.61
Estimated GFR at 12 months after transplantation (ml/min), mean (SD)
65 (19)
65 (16)
66 (22)
0.65</description><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNkE1OwzAQhS0EEqVwAHY-AGntBMfxMkqd1iK1q9ggdRW5ToxAQKsEFuw4Ou7Phh2rGc17b0bzAXCL0QQjlkw_2s_ps7cWJ2yiFYrZGRjh-xRFcZKRczAKHhwhgtgluBqGV4QQiykdgZ-DuRS1NnDN8xrWXOYVVI-mUEsOVQlNnUu9qnJpciOU1PvZg5hJvtawrNUSLvgqKEZoWEAhS14YPoMzJVWtoVF_ZMnnoX_i4UohVoJLo6_BhbdvQ3dzqmNgSm6KRVSpuSjyKnKUsWjTEuJavCEZ9l2KiHXYJ8RTZAn2bkNwklFis5i5LI1x-LnrXNamraedox7bZAzwca3rt8PQd77Z9S_vtv9uMGr2BJtAsDkRbA5QQubumNl-7f5h_wUb8WtQ</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Molnar, Miklos Zsolt</creator><creator>Talwar, Manish</creator><creator>Balaraman, Vasanthi</creator><creator>Bhalla, Anshul</creator><creator>Azhar, Ambreen</creator><creator>Yazawa, Masahiko</creator><creator>Tsujita, Makoto</creator><creator>Podila, Pradeep</creator><creator>Nair, Satheesh</creator><creator>Eason, James</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200601</creationdate><title>SO029FIRST YEAR RENAL OUTCOME OF TRANSPLANTATIONS OF KIDNEYS FROM HEPATITIS C INFECTED DONORS TO HEPATITIS C NEGATIVE RECIPIENTS</title><author>Molnar, Miklos Zsolt ; Talwar, Manish ; Balaraman, Vasanthi ; Bhalla, Anshul ; Azhar, Ambreen ; Yazawa, Masahiko ; Tsujita, Makoto ; Podila, Pradeep ; Nair, Satheesh ; Eason, James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c799-bd55cd1b581fe605ac1f35f70a51fcb513875a829c8621238eec8d6df7ec7f1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Molnar, Miklos Zsolt</creatorcontrib><creatorcontrib>Talwar, Manish</creatorcontrib><creatorcontrib>Balaraman, Vasanthi</creatorcontrib><creatorcontrib>Bhalla, Anshul</creatorcontrib><creatorcontrib>Azhar, Ambreen</creatorcontrib><creatorcontrib>Yazawa, Masahiko</creatorcontrib><creatorcontrib>Tsujita, Makoto</creatorcontrib><creatorcontrib>Podila, Pradeep</creatorcontrib><creatorcontrib>Nair, Satheesh</creatorcontrib><creatorcontrib>Eason, James</creatorcontrib><collection>CrossRef</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Molnar, Miklos Zsolt</au><au>Talwar, Manish</au><au>Balaraman, Vasanthi</au><au>Bhalla, Anshul</au><au>Azhar, Ambreen</au><au>Yazawa, Masahiko</au><au>Tsujita, Makoto</au><au>Podila, Pradeep</au><au>Nair, Satheesh</au><au>Eason, James</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SO029FIRST YEAR RENAL OUTCOME OF TRANSPLANTATIONS OF KIDNEYS FROM HEPATITIS C INFECTED DONORS TO HEPATITIS C NEGATIVE RECIPIENTS</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><date>2020-06-01</date><risdate>2020</risdate><volume>35</volume><issue>Supplement_3</issue><issn>0931-0509</issn><eissn>1460-2385</eissn><abstract>Abstract
Background and Aims
Transplant centers in US are increasingly willing to transplant kidneys from hepatitis C infected donors to hepatitis C negative recipients. Long-term renal outcome data from non-prophylactic treatment approach outside clinical trials is missing.
Method
We compared kidney graft function of 132 hepatitis C negative recipients, who received HCV infected (NAT+ and antibody+/-; HCV+) versus HCV negative (NAT- and antibody-; HCV-) in 2018, in a single center, retrospective, observational study. Categorical variables were compared using χ2 tests and continuous variables were compared using t-tests or Mann–Whitney U-tests, as appropriate. Linear regression was applied to assess independent association between graft function and HCV viremic status.
Results
The mean±SD age of recipients was 52±11 years, 44% were female, 20% and 79% of recipients were Caucasian and African-American, respectively. Baseline characteristics were similar between HCV+ vs HCV- groups, except dialysis duration, donors race, KDPI and cold ischemic time (Table). The DGF rate, estimated GFRs at post-transplant 3, 6, 9 and 12 months was similar between HCV+ and HCV- groups (Table). HCV viremic status was not a predictor of 3, 6, 9 and 12 months eGFR in our unadjusted model and after adjustment for donor and recipient characteristics.
Conclusion
Recipients of HCV-viremic kidneys have similar renal allograft function in the first year after transplantation compared to those who received from HCV-non-viremic kidneys.
Table:
Parameter
Entire cohort
HCV+
HCV-
P-value
Observations (n)
132
73
59
Recipient baseline characteristics
Age (years), mean (SD)
52 (11)
52 (11)
52 (12)
0.86
Female gender, N, (%)
58 (44%)
30 (41%)
28 (47%)
0.46
Race, N, (%)
Caucasian
27 (20%)
14 (19%)
13 (22%)
0.62
African American
104 (79%)
58 (80%)
46 (78%)
Other
1 (1%)
1 (1%)
0 (0%)
Dialysis duration (months), median (IQR)
60 (37-87)
49 (30-75)
71 (50-98)
<0.01
Comorbidity, N, (%)
Diabetes
61 (46%)
36 (49%)
25 (42%)
0.43
Hypertension
128 (97%)
71 (97%)
57 (97%)
0.83
Peripheral vascular disease
9 (7%)
8 (11%)
1 (2%)
0.04
Coronary artery disease
21 (16%)
11 (15%)
10 (17%)
0.74
Chronic obstructive pulmonary disease
8 (6%)
5 (7%)
3 (5%)
0.67
Donor Characteristics
Age (years), mean (SD)
33 (10)
32 (5)
34 (13)
0.17
Female gender, N, (%)
60 (45%)
37 (47%)
26 (44%)
0.77
DCD, N, (%)
18 (14%)
8 (11%)
10 (17%)
0.32
Comorbidity, N, (%)
Diabetes
2 (2%)
1 (1%)
1 (2%)
0.88
Hypertension
12 (9%)
6 (8%)
6 (10%)
0.70
Race, N, (%)
Caucasian
107 (82%)
70 (96%)
37 (64%)
<0.01
African American
21 (16%)
0 (0%)
21 (36%)
Other
3 (2%)
3 (4%)
0 (0%)
KDPI, mean (SD)
45 (19)
50 (16)
38 (21)
<0.01
Transplant characteristics
Cold Ischemic Time (hours), median (IQR)
18.2 (12.7- 21.8)
19.3 (16.2- 23.2)
15.3 (9.1- 20.3)
<0.01
ATG dose (mg/kg), mean (SD)
4.9 (0.9)
4.8 (0.8)
5.0 (1.3)
0.25
Renal Outcome Data
Delayed Graft Function, N, (%)
13 (10%)
6 (8%)
7 (12%)
0.49
Estimated GFR at 3 months after transplantation (ml/min), mean (SD)
63 (19)
63 (17)
64 (21)
0.76
Estimated GFR at 6 months after transplantation (ml/min), mean (SD)
66 (19)
66 (17)
66 (21)
0.97
Estimated GFR at 9 months after transplantation (ml/min), mean (SD)
66 (17)
66 (15)
67 (20)
0.61
Estimated GFR at 12 months after transplantation (ml/min), mean (SD)
65 (19)
65 (16)
66 (22)
0.65</abstract><pub>Oxford University Press</pub><doi>10.1093/ndt/gfaa139.SO029</doi></addata></record> |
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title | SO029FIRST YEAR RENAL OUTCOME OF TRANSPLANTATIONS OF KIDNEYS FROM HEPATITIS C INFECTED DONORS TO HEPATITIS C NEGATIVE RECIPIENTS |
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