SO029FIRST YEAR RENAL OUTCOME OF TRANSPLANTATIONS OF KIDNEYS FROM HEPATITIS C INFECTED DONORS TO HEPATITIS C NEGATIVE RECIPIENTS

Abstract Background and Aims Transplant centers in US are increasingly willing to transplant kidneys from hepatitis C infected donors to hepatitis C negative recipients. Long-term renal outcome data from non-prophylactic treatment approach outside clinical trials is missing. Method We compared kidney graft function of 132 hepatitis C negative recipients, who received HCV infected (NAT+ and antibody+/-; HCV+) versus HCV negative (NAT- and antibody-; HCV-) in 2018, in a single center, retrospective, observational study. Categorical variables were compared using χ2 tests and continuous variables were compared using t-tests or Mann–Whitney U-tests, as appropriate. Linear regression was applied to assess independent association between graft function and HCV viremic status. Results The mean±SD age of recipients was 52±11 years, 44% were female, 20% and 79% of recipients were Caucasian and African-American, respectively. Baseline characteristics were similar between HCV+ vs HCV- groups, except dialysis duration, donors race, KDPI and cold ischemic time (Table). The DGF rate, estimated GFRs at post-transplant 3, 6, 9 and 12 months was similar between HCV+ and HCV- groups (Table). HCV viremic status was not a predictor of 3, 6, 9 and 12 months eGFR in our unadjusted model and after adjustment for donor and recipient characteristics. Conclusion Recipients of HCV-viremic kidneys have similar renal allograft function in the first year after transplantation compared to those who received from HCV-non-viremic kidneys. Table: Parameter Entire cohort HCV+ HCV- P-value Observations (n) 132 73 59 Recipient baseline characteristics Age (years), mean (SD) 52 (11) 52 (11) 52 (12) 0.86 Female gender, N, (%) 58 (44%) 30 (41%) 28 (47%) 0.46 Race, N, (%) Caucasian 27 (20%) 14 (19%) 13 (22%) 0.62 African American 104 (79%) 58 (80%) 46 (78%) Other 1 (1%) 1 (1%) 0 (0%) Dialysis duration (months), median (IQR) 60 (37-87) 49 (30-75) 71 (50-98)