Acridone-labeled DNA aptamer for the detection of biomolecules

Acridone-labeled DNA aptamer for the detection of biomolecules

Abstract An acridone-labeled DNA aptamer was synthesized to produce an aptamer probe. This aptamer probe could detect a specific molecule based on conformational changes upon binding of the specific molecules and the quenching of acridone emission.

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Veröffentlicht in:Nucleic Acids Symposium Series 2009, Vol.53 (1), p.255-256
Hauptverfasser: Ozaki, Hiroaki, Hagiwara, Yasuhisa, Asakura, Hiromi, Kuwahara, Masayasu
Format: Artikel
Sprache:eng
Schlagworte:
Acridines - chemistry
Acridones
Aptamers, Nucleotide - chemistry
Arginine - analogs & derivatives
Arginine - analysis
DNA - chemistry
Fluorescent Dyes - chemistry
Oligodeoxyribonucleotides - chemistry
Spectrometry, Fluorescence
Temperature
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Zusammenfassung:Abstract An acridone-labeled DNA aptamer was synthesized to produce an aptamer probe. This aptamer probe could detect a specific molecule based on conformational changes upon binding of the specific molecules and the quenching of acridone emission.
ISSN:0261-3166
1746-8272
DOI:10.1093/nass/nrp128