Crown ether ring-fused nucleosides: synthesis and conformational properties

Abstract We here describe the synthesis of a series of novel bicyclic ribonucleoside derivatives, with 18-crown-6 ether moieties attached via their ribose 2- and 3- positions, as first examples of crown ether ring-fused nucleosides, to be evaluated as antiviral and/or antitumoral agents.

Bibliographische Detailangaben

Veröffentlicht in:	Nucleic Acids Symposium Series 2008, Vol.52 (1), p.667-668
Hauptverfasser:	Coppola, Cinzia, D'Onofrio, Jennifer, Fabio, Giovanni Di, Napoli, Lorenzo De, Montesarchio, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Crown Ethers - chemical synthesis Crown Ethers - chemistry Nucleic Acid Conformation Ribonucleosides - chemical synthesis Ribonucleosides - chemistry
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