Crown ether ring-fused nucleosides: synthesis and conformational properties

Crown ether ring-fused nucleosides: synthesis and conformational properties

Abstract We here describe the synthesis of a series of novel bicyclic ribonucleoside derivatives, with 18-crown-6 ether moieties attached via their ribose 2- and 3- positions, as first examples of crown ether ring-fused nucleosides, to be evaluated as antiviral and/or antitumoral agents.

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Veröffentlicht in:Nucleic Acids Symposium Series 2008, Vol.52 (1), p.667-668
Hauptverfasser: Coppola, Cinzia, D'Onofrio, Jennifer, Fabio, Giovanni Di, Napoli, Lorenzo De, Montesarchio, Daniela
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antiviral Agents - chemical synthesis
Antiviral Agents - chemistry
Crown Ethers - chemical synthesis
Crown Ethers - chemistry
Nucleic Acid Conformation
Ribonucleosides - chemical synthesis
Ribonucleosides - chemistry
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Zusammenfassung:Abstract We here describe the synthesis of a series of novel bicyclic ribonucleoside derivatives, with 18-crown-6 ether moieties attached via their ribose 2- and 3- positions, as first examples of crown ether ring-fused nucleosides, to be evaluated as antiviral and/or antitumoral agents.
ISSN:0261-3166
1746-8272
DOI:10.1093/nass/nrn337