Crown ether ring-fused nucleosides: synthesis and conformational properties
Abstract We here describe the synthesis of a series of novel bicyclic ribonucleoside derivatives, with 18-crown-6 ether moieties attached via their ribose 2- and 3- positions, as first examples of crown ether ring-fused nucleosides, to be evaluated as antiviral and/or antitumoral agents.
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| Veröffentlicht in: | Nucleic Acids Symposium Series 2008, Vol.52 (1), p.667-668 |
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| container_end_page | 668 |
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| container_issue | 1 |
| container_start_page | 667 |
| container_title | Nucleic Acids Symposium Series |
| container_volume | 52 |
| creator | Coppola, Cinzia D'Onofrio, Jennifer Fabio, Giovanni Di Napoli, Lorenzo De Montesarchio, Daniela |
| description | Abstract
We here describe the synthesis of a series of novel bicyclic ribonucleoside derivatives, with 18-crown-6 ether moieties attached via their ribose 2- and 3- positions, as first examples of crown ether ring-fused nucleosides, to be evaluated as antiviral and/or antitumoral agents. |
| doi_str_mv | 10.1093/nass/nrn337 |
| format | Article |
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We here describe the synthesis of a series of novel bicyclic ribonucleoside derivatives, with 18-crown-6 ether moieties attached via their ribose 2- and 3- positions, as first examples of crown ether ring-fused nucleosides, to be evaluated as antiviral and/or antitumoral agents.</description><identifier>ISSN: 0261-3166</identifier><identifier>EISSN: 1746-8272</identifier><identifier>DOI: 10.1093/nass/nrn337</identifier><identifier>PMID: 18776556</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antiviral Agents - chemical synthesis ; Antiviral Agents - chemistry ; Crown Ethers - chemical synthesis ; Crown Ethers - chemistry ; Nucleic Acid Conformation ; Ribonucleosides - chemical synthesis ; Ribonucleosides - chemistry</subject><ispartof>Nucleic Acids Symposium Series, 2008, Vol.52 (1), p.667-668</ispartof><rights>2008 Oxford University Press 2008</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2717-8019ef43cbf712480c5c1257fe0e003219e94321682df7c258cfe76222e56cdb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1603,4022,27922,27923,27924</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/nass/nrn337$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18776556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coppola, Cinzia</creatorcontrib><creatorcontrib>D'Onofrio, Jennifer</creatorcontrib><creatorcontrib>Fabio, Giovanni Di</creatorcontrib><creatorcontrib>Napoli, Lorenzo De</creatorcontrib><creatorcontrib>Montesarchio, Daniela</creatorcontrib><title>Crown ether ring-fused nucleosides: synthesis and conformational properties</title><title>Nucleic Acids Symposium Series</title><addtitle>Nucleic Acids Symp Ser (Oxf)</addtitle><description>Abstract
We here describe the synthesis of a series of novel bicyclic ribonucleoside derivatives, with 18-crown-6 ether moieties attached via their ribose 2- and 3- positions, as first examples of crown ether ring-fused nucleosides, to be evaluated as antiviral and/or antitumoral agents.</description><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antiviral Agents - chemical synthesis</subject><subject>Antiviral Agents - chemistry</subject><subject>Crown Ethers - chemical synthesis</subject><subject>Crown Ethers - chemistry</subject><subject>Nucleic Acid Conformation</subject><subject>Ribonucleosides - chemical synthesis</subject><subject>Ribonucleosides - chemistry</subject><issn>0261-3166</issn><issn>1746-8272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS0EolXpxI4ywYBC_UjshA1VvEQlFpit1LmGoMQOvolQ_z2uUomNu5zhfDpX-gg5Z_SG0VKsXIW4csEJoY7InKlMpgVX_JjMKZcsFUzKGVkiftF4GaWqVKdkxgqlZJ7LOXlZB__jEhg-ISShcR-pHRHqxI2mBY9NDXib4M7FHhtMKlcnxjvrQ1cNjXdVm_TB9xCGBvCMnNiqRVgeckHeH-7f1k_p5vXxeX23SQ1XTKUFZSXYTJitVYxnBTW5YTxXFihQKnhsyyyGLHhtleF5YSwoyTmHXJp6KxbkatqNr79HwEF3DRpo28qBH1GrKCPjIssjeT2RJnjEAFb3oemqsNOM6r0_vfenJ3-RvjjsjtsO6j_2YCsClxPgx_7fpV_45Hn2</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Coppola, Cinzia</creator><creator>D'Onofrio, Jennifer</creator><creator>Fabio, Giovanni Di</creator><creator>Napoli, Lorenzo De</creator><creator>Montesarchio, Daniela</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Crown ether ring-fused nucleosides: synthesis and conformational properties</title><author>Coppola, Cinzia ; D'Onofrio, Jennifer ; Fabio, Giovanni Di ; Napoli, Lorenzo De ; Montesarchio, Daniela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2717-8019ef43cbf712480c5c1257fe0e003219e94321682df7c258cfe76222e56cdb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antiviral Agents - chemical synthesis</topic><topic>Antiviral Agents - chemistry</topic><topic>Crown Ethers - chemical synthesis</topic><topic>Crown Ethers - chemistry</topic><topic>Nucleic Acid Conformation</topic><topic>Ribonucleosides - chemical synthesis</topic><topic>Ribonucleosides - chemistry</topic><toplevel>online_resources</toplevel><creatorcontrib>Coppola, Cinzia</creatorcontrib><creatorcontrib>D'Onofrio, Jennifer</creatorcontrib><creatorcontrib>Fabio, Giovanni Di</creatorcontrib><creatorcontrib>Napoli, Lorenzo De</creatorcontrib><creatorcontrib>Montesarchio, Daniela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nucleic Acids Symposium Series</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Coppola, Cinzia</au><au>D'Onofrio, Jennifer</au><au>Fabio, Giovanni Di</au><au>Napoli, Lorenzo De</au><au>Montesarchio, Daniela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crown ether ring-fused nucleosides: synthesis and conformational properties</atitle><jtitle>Nucleic Acids Symposium Series</jtitle><addtitle>Nucleic Acids Symp Ser (Oxf)</addtitle><date>2008</date><risdate>2008</risdate><volume>52</volume><issue>1</issue><spage>667</spage><epage>668</epage><pages>667-668</pages><issn>0261-3166</issn><eissn>1746-8272</eissn><abstract>Abstract
We here describe the synthesis of a series of novel bicyclic ribonucleoside derivatives, with 18-crown-6 ether moieties attached via their ribose 2- and 3- positions, as first examples of crown ether ring-fused nucleosides, to be evaluated as antiviral and/or antitumoral agents.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>18776556</pmid><doi>10.1093/nass/nrn337</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0261-3166 |
| ispartof | Nucleic Acids Symposium Series, 2008, Vol.52 (1), p.667-668 |
| issn | 0261-3166 1746-8272 |
| language | eng |
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| source | Oxford Journals Open Access Collection |
| subjects | Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Crown Ethers - chemical synthesis Crown Ethers - chemistry Nucleic Acid Conformation Ribonucleosides - chemical synthesis Ribonucleosides - chemistry |
| title | Crown ether ring-fused nucleosides: synthesis and conformational properties |
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