Nucleosides with 1,4-dioxane as sugar moiety

Abstract A synthetic route towards novel nucleosides with 1,4- dioxane as the sugar moiety has been developed. The dioxane moiety features a second anomeric center, which has been phosphitylated giving a diastereomeric mixture of the corresponding phosphoramidites.

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Bibliographische Detailangaben
Veröffentlicht in:	Nucleic Acids Symposium Series 2008, Vol.52 (1), p.269-270
Hauptverfasser:	Madsen, Andreas Stahl, Langkjær, Niels, Wengel, Jesper
Format:	Artikel
Sprache:	eng
Schlagworte:	Dioxanes - chemistry Nucleosides - chemical synthesis Nucleosides - chemistry Organophosphorus Compounds - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	Abstract A synthetic route towards novel nucleosides with 1,4- dioxane as the sugar moiety has been developed. The dioxane moiety features a second anomeric center, which has been phosphitylated giving a diastereomeric mixture of the corresponding phosphoramidites.
ISSN:	0261-3166 1746-8272
DOI:	10.1093/nass/nrn136