Pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H, 3H, 6H, 8H)-tetraone as a novel universal base

Pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H, 3H, 6H, 8H)-tetraone as a novel universal base

A derivative of pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone (PPT), which may form various keto-enol tautomers suitable for forming base pairs with all natural bases, and is thus expected to serve as a universal base, was synthesized. The ability of PPT to form base pairs with natural ba...

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Veröffentlicht in:Nucleic Acids Symposium Series 2005-09, Vol.49 (1), p.119-120
Hauptverfasser: Kataoka, Masanori, Hirano, Taisuke, Kuroda, Kenji, Hayakawa, Yoshihiro
Format: Artikel
Sprache:eng
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Zusammenfassung:A derivative of pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone (PPT), which may form various keto-enol tautomers suitable for forming base pairs with all natural bases, and is thus expected to serve as a universal base, was synthesized. The ability of PPT to form base pairs with natural bases was evaluated by UV analysis.
ISSN:0261-3166
1746-8272
DOI:10.1093/nass/49.1.119